抗抑郁药噻奈普汀对大鼠前额叶皮质和伏隔核多巴胺能代谢影响的差异。一项伏安法研究。

Difference in the effects of the antidepressant tianeptine on dopaminergic metabolism in the prefrontal cortex and the nucleus accumbens of the rat. A voltammetric study.

作者信息

Louilot A, Mocaer E, Simon H, Le Moal M

机构信息

Laboratoire de Psychobiologie des Comportements Adaptatifs - INSERM U.259, Université de Bordeaux II, France.

出版信息

Life Sci. 1990;47(13):1083-9. doi: 10.1016/0024-3205(90)90166-o.

DOI:10.1016/0024-3205(90)90166-o

PMID:2233128

Abstract

The effects of the new tricyclic antidepressant tianeptine were investigated on dopaminergic (DAergic) metabolism in the anteromedian prefrontal cortex and the nucleus accumbens of the rat. DAergic metabolism was assessed by the measurement of DOPAC, the main presynaptic metabolite of dopamine, using in vivo voltammetry in rats ventilated with halothane (0.5-0.75% in air). Acute treatment with tianeptine (10 mg/kg, 20 mg/kg) only increased significantly DOPAC levels in the anteromedian prefrontal cortex. After chronic treatment with tianeptine (15 days, 2 times/day) the increases in DOPAC levels in this structure were altered and less pronounced with the 20 mg/kg dose. Previous studies led to suggest that both acute and chronic effects on DAergic terminals in the anteromedian prefrontal cortex may be involved in the therapeutic action of this new antidepressant.

摘要

研究了新型三环类抗抑郁药噻奈普汀对大鼠前额叶内侧皮质和伏隔核中多巴胺能（DAergic）代谢的影响。通过测量多巴胺的主要突触前代谢产物3,4-二羟基苯乙酸（DOPAC）来评估DAergic代谢，采用体内伏安法，对用氟烷（空气中0.5 - 0.75%）通气的大鼠进行检测。噻奈普汀急性治疗（10 mg/kg，20 mg/kg）仅显著增加了前额叶内侧皮质中的DOPAC水平。噻奈普汀慢性治疗（15天，每天2次）后，该结构中DOPAC水平的升高发生改变，20 mg/kg剂量时变化不那么明显。先前的研究表明，对前额叶内侧皮质中DAergic终末的急性和慢性影响可能都参与了这种新型抗抑郁药的治疗作用。