Department of Bioengineering, University of Toledo, Toledo, Ohio, USA.
J Biomed Mater Res B Appl Biomater. 2012 May;100(4):1142-50. doi: 10.1002/jbm.b.32681. Epub 2012 Feb 14.
Amorphous calcium phosphate (ACP) is an important precursor phase in tissue mineralization. It shows high solubility and excellent remineralization ability. Commercially viable techniques for producing ACP are high-cost/low-efficiency process. This article describes a novel microwave (MW)-assisted ACP synthesis route as an alternative to current ACP synthesis methods. An important feature of the process is the use of supersaturated biomimetic fluids (SBFs), which are based on Kokubo-like simulated body fluids. However, our present compositions are substantially different in that they no longer simulate the body fluid compositions. The effects of solution composition and processing parameters were studied. The mechanism of ACP synthesis under MW irradiation process is also discussed. The as-synthesized ACP nanospheres were characterized and showed good reactivity and biocompatibility. These as-synthesized nanoparticles can be potential candidates for biomedical applications and remineralization mechanism study.
无定形磷酸钙 (ACP) 是组织矿化的重要前体相。它具有高溶解度和优异的再矿化能力。目前用于生产 ACP 的商业可行技术是高成本/低效率的工艺。本文介绍了一种新的微波 (MW) 辅助 ACP 合成途径，作为当前 ACP 合成方法的替代方法。该工艺的一个重要特点是使用过饱和仿生液 (SBF)，其基于类似 Kokubo 的模拟体液。然而，我们目前的组成在很大程度上有所不同，因为它们不再模拟体液组成。研究了溶液组成和处理参数的影响。还讨论了 MW 辐照过程中 ACP 合成的机理。所合成的 ACP 纳米球进行了表征，显示出良好的反应性和生物相容性。这些合成的纳米颗粒可能是生物医学应用和再矿化机制研究的潜在候选者。
