Kazakova Gilyana, Safronova Tatiana, Golubchikov Daniil, Shevtsova Olga, Rau Julietta V
Department of Materials Science, Lomonosov Moscow State University, Laboratory Building B, 1-73 Leninskiye Gory, Moscow 119991, Russia.
Department of Chemistry, Lomonosov Moscow State University, GSP-1, 1-3 Leninskiye Gory, Moscow 119991, Russia.
Materials (Basel). 2021 Aug 26;14(17):4857. doi: 10.3390/ma14174857.
Materials based on Mg-containing phosphates are gaining great relevance in the field of bone tissue repair via regenerative medicine methods. Magnesium ions, together with condensed phosphate ions, play substantial roles in the process of bone remodeling, affecting the early stage of bone regeneration through active participation in the process of osteosynthesis. In this paper we provide a comprehensive overview of the usage of biomaterials based on magnesium phosphate and magnesium calcium phosphate in bone reconstruction. We consider the role of magnesium ions in angiogenesis, which is an important process associated with osteogenesis. Finally, we summarize the biological properties of calcium magnesium phosphates for regeneration of bone.
基于含镁磷酸盐的材料在通过再生医学方法进行骨组织修复领域正变得极具重要性。镁离子与缩合磷酸根离子一起，在骨重塑过程中发挥重要作用，通过积极参与骨合成过程影响骨再生的早期阶段。在本文中，我们全面概述了基于磷酸镁和磷酸镁钙的生物材料在骨重建中的应用。我们考虑了镁离子在血管生成中的作用，血管生成是与骨生成相关的一个重要过程。最后，我们总结了磷酸钙镁用于骨再生的生物学特性。
