细胞内叶酸的转运。
Trafficking of intracellular folates.
机构信息
Cornell University, Division of Nutritional Sciences, Ithaca, NY 14850, USA.
出版信息
Adv Nutr. 2011 Jul;2(4):325-31. doi: 10.3945/an.111.000596. Epub 2011 Jun 28.
Abstract
The role of metabolic compartmentation in spatially organizing metabolic enzymes into pathways, regulating flux through metabolic pathways, and controlling the partitioning of metabolic intermediates among pathways is appreciated, but our understanding of the mechanisms that establish metabolic architecture and mediate communication and regulation among interconnected metabolic pathways and networks is still incomplete. This review discusses recent advancements in our understanding of metabolic compartmentation within the pathways that constitute the folate-mediated one-carbon metabolic network and emerging evidence for a need to regulate the trafficking of folates among compartmentalized metabolic pathways.
摘要
代谢区室在将代谢酶沿代谢途径进行空间组织、调节代谢途径中的通量以及控制代谢中间产物在途径间分配方面的作用已得到认可，但我们对建立代谢架构的机制以及对相互连接的代谢途径和网络之间的通讯和调节的理解仍不完整。本文综述了我们在构成叶酸介导的一碳代谢网络的途径中对代谢区室的理解的最新进展，以及需要调节叶酸在分隔代谢途径中的运输的新证据。
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