Imperial College London, St Mary's Hospital, London, UK.
Sex Transm Infect. 2012 Aug;88(5):335-41. doi: 10.1136/sextrans-2011-050371. Epub 2012 Feb 13.
To assess adherence to post-exposure prophylaxis (PEP) for the prevention of HIV infection in victims of sexual assault.
The authors carried out a systematic review, random effects meta-analysis and meta-regression of studies reporting adherence to PEP among victims of sexual violence. Seven electronic databases were searched. Our primary outcome was adherence; secondary outcomes included defaulting, refusal and side effects.
2159 titles were screened, and 24 studies matching the inclusion criteria were taken through to analysis. The overall proportion of patients adhering to PEP (23 cohort studies, 2166 patients) was 40.3% (95% CI 32.5% to 48.1%), and the overall proportion of patients defaulting from care (18 cohorts, 1972 patients) was 41.2% (95% CI 31.1% to 51.4%). Adherence appeared to be higher in developing countries compared with developed countries.
Adherence to PEP is poor in all settings. Interventions are needed to support adherence.
评估性侵犯受害者接受暴露后预防（PEP）以预防 HIV 感染的依从性。
作者对报告性暴力受害者 PEP 依从性的研究进行了系统评价、随机效应荟萃分析和荟萃回归。检索了 7 个电子数据库。我们的主要结局是依从性；次要结局包括停药、拒绝和副作用。
筛选出 2159 个标题，并对符合纳入标准的 24 项研究进行了分析。总体上，PEP 依从性（23 项队列研究，2166 名患者）的比例为 40.3%（95%CI 32.5%至 48.1%），总体停药比例（18 项队列研究，1972 名患者）为 41.2%（95%CI 31.1%至 51.4%）。与发达国家相比，发展中国家的 PEP 依从性似乎更高。
在所有环境中，PEP 的依从性都很差。需要采取干预措施来支持依从性。
