Perrotin Audrey, Mormino Elizabeth C, Madison Cindee M, Hayenga Amynta O, Jagust William J
Helen Wills Neuroscience Institute, University of California, Berkeley, CA, USA
Arch Neurol. 2012 Feb;69(2):223-9. doi: 10.1001/archneurol.2011.666.
To study the relationship between subjective cognition and the neuropathological hallmark of Alzheimer disease (AD), amyloid-β (Aβ) deposition, using carbon 11-labeled Pittsburgh Compound B (PiB) positron emission tomography in normal elderly individuals.
Cross-sectional analysis.
Forty-eight cognitively normal elderly subjects (11 with high PiB uptake and 28 with low PiB uptake) were included. All underwent clinical and neuropsychological evaluations, magnetic resonance imaging, and positron emission tomography.
Berkeley Aging Cohort Study.
Relationship between PiB uptake and subjective cognition measures.
Subjects with high PiB uptake showed significantly lower performance than those with low PiB uptake on an episodic memory measure and were less confident about their general memory abilities when required to evaluate themselves relative to other people of the same age. High and low PiB uptake groups did not differ on the accuracy of their cognitive self-reports compared with objective cognitive performance. General memory self-reports from the whole group were significantly correlated with regional PiB uptake in the right medial prefrontal cortex and anterior cingulate cortex and in the right precuneus and posterior cingulate cortex. Reduced confidence about memory abilities was associated with greater PiB uptake in these brain regions. All results were independent of demographic variables and depressive affects.
A decrease of self-confidence about memory abilities in cognitively normal elderly subjects may be related to the neuropathological hallmark of AD measured with PiB-positron emission tomography. Subjective cognitive impairment may represent a very early clinical manifestation of AD.
在正常老年个体中，使用碳11标记的匹兹堡化合物B（PiB）正电子发射断层扫描技术，研究主观认知与阿尔茨海默病（AD）神经病理学标志物淀粉样β蛋白（Aβ）沉积之间的关系。
横断面分析。
纳入48名认知正常的老年受试者（11名PiB摄取高者和28名PiB摄取低者）。所有受试者均接受了临床和神经心理学评估、磁共振成像及正电子发射断层扫描。
伯克利衰老队列研究。
PiB摄取与主观认知指标之间的关系。
在情景记忆测试中，PiB摄取高的受试者表现显著低于PiB摄取低的受试者，并且在被要求与同龄人比较评估自身总体记忆能力时，他们对自己的记忆能力信心较低。与客观认知表现相比，PiB摄取高和低的两组在认知自我报告的准确性方面没有差异。整个组的总体记忆自我报告与右侧内侧前额叶皮质、前扣带回皮质以及右侧楔前叶和后扣带回皮质的局部PiB摄取显著相关。对记忆能力信心降低与这些脑区中更高的PiB摄取相关。所有结果均独立于人口统计学变量和抑郁影响。
认知正常的老年受试者对记忆能力的自信心下降可能与用PiB正电子发射断层扫描测量的AD神经病理学标志物有关。主观认知障碍可能代表AD非常早期的临床表现。
