Department of Psychiatry, University of Bonn, Germany.
Dement Geriatr Cogn Disord. 2010;29(1):75-81. doi: 10.1159/000264630. Epub 2010 Jan 28.
BACKGROUND/AIMS: Subjective memory impairment (SMI) has been suggested as a manifestation of Alzheimer's Disease (AD) preceding mild cognitive impairment (MCI). In this study, we determined the volumes of the hippocampus, the entorhinal cortex (EC) and the amygdala to provide biological evidence for AD in SMI.
Regional volumetric measures were manually traced on 3-Tesla MRI scans.
Total brain volume did not differ between the groups. Individuals with SMI had reduced volumes of the hippocampus bilaterally (right p = 0.001; left p < 0.001), the bilateral EC (right p = 0.031, left p = 0.006) and the right amygdala (p = 0.01) compared to the control group.
Volume reduction of bilateral hippocampus, bilateral EC and right amygdala supports the concept of SMI as a very early manifestation of AD prior to MCI. SMI may indicate awareness of a degenerative process that can still be functionally compensated.
背景/目的：主观记忆障碍（SMI）被认为是阿尔茨海默病（AD）在轻度认知障碍（MCI）之前的表现。在这项研究中，我们确定了海马体、内嗅皮层（EC）和杏仁核的体积，为 SMI 中的 AD 提供生物学证据。
在 3T MRI 扫描上手动追踪区域容积测量值。
两组之间的总脑体积没有差异。与对照组相比，SMI 个体双侧海马体（右侧 p = 0.001；左侧 p < 0.001）、双侧 EC（右侧 p = 0.031，左侧 p = 0.006）和右侧杏仁核（p = 0.01）的体积减小。
双侧海马体、双侧 EC 和右侧杏仁核的体积减少支持 SMI 是 MCI 之前 AD 的早期表现的概念。SMI 可能表明对退行性过程的认识，该过程仍可在功能上得到补偿。
