[通过扩散张量磁共振成像比较有和无冲动行为的精神分裂症患者的白质完整性]

[Comparison of white matter integrity of schizophrenic patients with and without impulsive behaviors by diffusion tensor magnetic resonance imaging].

作者信息

Wei Qin-ling, Han Zi-li, Wu Xiao-li, Kang Zhuang, Li Lei-jun, Zheng Liang-rong, Guo Xiao-feng, Zhao Jing-ping, Zhang Jin-bei

机构信息

Department of Psychiatry, Third Affiliated Hospital, SUN Yat-sen University, Guangzhou, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2011 Nov 22;91(43):3030-3.

PMID:22333053

Abstract

OBJECTIVE

To compare the regional white matter integrity of schizophrenics with impulsive behaviors versus those without.

METHODS

Seventeen patients with first-episode-schizophrenia impulsive behaviors and 24 patients with first-episode-schizophrenia non-impulsive behaviors underwent diffusion weighted magnetic resonance imaging with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups received two-sample t-test with SPM5 software.

RESULTS

The patients with impulsive behaviors demonstrated a significant decrement of white matter FA values in left precentral gyrus (MNI: x = -28.00, y = -28.72, z = -54.71; cluster = 79 voxels), left cerebellum anterior lobe (MNI: x = -22, y = -56, z = -28; cluster = 130 voxels) and left occipital lobe (MNI: x = -6, y = -72, z = 6; cluster = 54 voxels).

CONCLUSION

The altered white matter integrity of left precentral gyrus, cerebellum anterior lobe and occipital lobe may be involved in the neural mechanism of impulsive behaviors in schizophrenia.

摘要

目的

比较有冲动行为的精神分裂症患者与无冲动行为的精神分裂症患者的局部白质完整性。

方法

17例首发精神分裂症伴冲动行为患者和24例首发精神分裂症无冲动行为患者接受了扩散加权磁共振成像，采用单次激发回波平面成像（EPI）序列，图像与直轴平面对齐。两组的分数各向异性（FA）图像用SPM5软件进行两样本t检验。

结果

有冲动行为的患者在左侧中央前回（MNI：x = -28.00，y = -28.72，z = -54.71；簇 = 79体素）、左侧小脑前叶（MNI：x = -22，y = -56，z = -28；簇 = 130体素）和左侧枕叶（MNI：x = -6，y = -72，z = 6；簇 = 54体素）的白质FA值显著降低。