Wei Qin-ling, Wang Yan-xin, Gan Zhao-yu, Li Lei-jun, Zheng Liang-rong, Guo Xiao-feng, Zhao Jing-ping, Zhang Jin-bei, Kang Zhuang
Department of Psychiatry, Third Affiliated Hospital, SUN Yat-sen University, Guangzhou 510630, China.
Zhonghua Yi Xue Za Zhi. 2012 May 22;92(19):1307-9.
To explore the roles of diffusion tensor imaging (DTI) of white matter at an early stage of schizophrenia.
The participants were 20 first-episode, medication-naïve schizophrenics at an early stage (1 - 6 months) and 20 healthy controls adjusted in gender and age during December 2009 and October 2010. They underwent diffusion weighted magnetic resonance imaging with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups underwent two-sample paired t-test with SPM5 software.
The schizophrenics at an early stage demonstrated a significant decrease of regional white matter FA values in right anterior cingulated (MNI: x = 12, y = 24, z = -10; cluster = 145) and right middle occipital lobe (MNI: x = 36, y = -76, z = -2; cluster = 135).
The altered white matter DTI in right anterior cingulated and middle occipital lobe may contribute to an early detection of schizophrenia.
探讨精神分裂症早期白质扩散张量成像（DTI）的作用。
选取20例首发、未用药的精神分裂症早期患者（病程1 - 6个月）以及20名在性别和年龄上匹配的健康对照者，研究时间为2009年12月至2010年10月。所有受试者均接受扩散加权磁共振成像，采用单次激发回波平面成像（EPI）序列，扫描层面与直轴平面平行。使用SPM5软件对两组的分数各向异性（FA）图像进行两样本配对t检验。
早期精神分裂症患者右侧前扣带回（MNI坐标：x = 12，y = 24，z = -10；簇体积 = 145）和右侧枕叶中部（MNI坐标：x = 36，y = -76，z = -2；簇体积 = 135）的白质FA值显著降低。
右侧前扣带回和枕叶中部白质DTI的改变可能有助于精神分裂症的早期检测。
