基于 2004-2005 年全国哨点监测数据的摩洛哥 HIV-1 亚型分布。

HIV-1 Subtype distribution in morocco based on national sentinel surveillance data 2004-2005.

机构信息

Department of Epidemiology and Emerging Pathogens Institute, University of Florida, Gainesville, USA.

出版信息

AIDS Res Ther. 2012 Feb 14;9(1):5. doi: 10.1186/1742-6405-9-5.

DOI:10.1186/1742-6405-9-5

PMID:22333070

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3308925/

Abstract

BACKGROUND

Little is known about HIV-1 subtype distribution in Morocco. Some data suggest an emergence of new HIV subtypes. We conducted phylogenetic analysis on a nationally representative sample of 60 HIV-1 viral specimens collected during 2004-2005 through the Morocco national HIV sentinel surveillance survey.

RESULTS

While subtype B is still the most prevalent, 23.3% of samples represented non-B subtypes, the majority of which were classified as CRF02_AG (15%). Molecular clock analysis confirmed that the initial introduction of HIV-1B in Morocco probably came from Europe in the early 1980s. In contrast, the CRF02_AG strain appeared to be introduced from sub-Saharan Africa in two separate events in the 1990s.

CONCLUSIONS

Subtype CRF02_AG has been emerging in Morocco since the 1990s. More information about the factors introducing HIV subtype-specific transmission will inform the prevention strategy in the region.

摘要

背景

摩洛哥的 HIV-1 亚型分布情况鲜为人知。一些数据表明新的 HIV 亚型正在出现。我们对 2004-2005 年通过摩洛哥全国 HIV 哨点监测调查收集的 60 份 HIV-1 病毒标本进行了全国代表性样本的系统进化分析。

结果

虽然 B 亚型仍然是最主要的流行亚型，但 23.3%的样本代表了非 B 亚型，其中大多数被归类为 CRF02_AG（15%）。分子钟分析证实，HIV-1B 最初在 20 世纪 80 年代初可能是从欧洲传入摩洛哥的。相比之下，CRF02_AG 株似乎是在 20 世纪 90 年代两次分别从撒哈拉以南非洲传入的。