Tsigkaropoulou Evdoxia, Peppa Melpomeni, Zompola Christina, Rizos Emmanouil, Xelioti Ioanna, Chatziioannou Sofia, Filippopoulou Anastasia, Lykouras Lefteris
2nd Department of Psychiatry, Medical School, University of Athens, Athens, Greece.
Gend Med. 2012 Feb;9(1):56-60. doi: 10.1016/j.genm.2012.01.001.
Hyperprolactinemia causes hypogonadotrophic hypogonadism. Hyperprolactinemia can be pre-existing in some patients with schizophrenia. Dopamine is the most important prolactin-inhibiting factor, and dopaminergic hyperactivity has been implicated in the pathophysiology of psychosis.
Since dopamine is a prolactin-inhibiting factor and dopamine imbalanced has been implicated in the pathophysiology of psychotic disorders, we investigated the probable relationship between hyperprolactinemia and the development of psychotic symptoms, in a patient with hypogonadism due to hyperprolactnemia and subsequent first episode of psychosis. Since dopamine is a prolactin-inhibiting factor and dopamine imbalance has been implicated in the pathophysiology of psychotic disorders, we investigated the probable relationship between hyperprolactinemia and the development of psychotic symptoms.
We present the case of a patient with hypogonadism secondary to chronic, untreated hyperprolactinemia who developed acute psychotic symptoms.
Psychotic symptoms resolved soon after treatment with aripiprazole in conjunction with cabergoline, with a concomitant decrease in serum prolactin level.
This is an interesting case illustrating a complicated relationship among hypogonadism secondary to a prolactinoma and dopamine and psychosis.
高催乳素血症会导致低促性腺激素性性腺功能减退。高催乳素血症在一些精神分裂症患者中可能预先存在。多巴胺是最重要的催乳素抑制因子，多巴胺能亢进与精神病的病理生理学有关。
由于多巴胺是一种催乳素抑制因子，且多巴胺失衡与精神障碍的病理生理学有关，我们调查了一名因高催乳素血症导致性腺功能减退并随后首次出现精神病发作的患者中，高催乳素血症与精神病症状发展之间的可能关系。由于多巴胺是一种催乳素抑制因子，且多巴胺失衡与精神障碍的病理生理学有关，我们调查了高催乳素血症与精神病症状发展之间的可能关系。
我们报告了一例继发于慢性未经治疗的高催乳素血症且出现急性精神病症状的性腺功能减退患者的病例。
使用阿立哌唑联合卡麦角林治疗后，精神病症状很快得到缓解，同时血清催乳素水平下降。
这是一个有趣的病例，说明了催乳素瘤继发的性腺功能减退、多巴胺和精神病之间的复杂关系。
