[低剂量计算机断层扫描筛查高危人群早期肺癌：一项荟萃分析]

[Screening of early lung cancer with low-dose computed tomography in high-risk populations: a meta-analysis].

作者信息

Yao Yan-wen, Yuan Dong-mei, Lü Yan-ling, Li Yu-feng, Song Yong

机构信息

Department of Respiratory Diseases, Nanjing General Hospital of Nanjing Military Command, Medical School of Nanjing University, Nanjing 210002, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2011 Nov 1;91(40):2819-23.

PMID:22333541

Abstract

OBJECTIVE

To explore the values of low-dose computed tomography (LDCT) in the screening of high-risk populations for early lung cancer through a meta-analysis of the relevant literature.

METHODS

PubMed, EBSCO, Cochrane and other databases were searched with key words. And the studies were selected by the inclusion and exclusion criteria. The baseline data were collected and analyzed by statistical software.

RESULTS

Ten random controlled trials (RCTs) were selected. Compared to the chest X ray (CXR) screening and no screening controls, LDCT screening had an odds ratio (OR) of 3.705, 95%CI 3.527 - 3.891. And in the subgroup analysis, a higher number of stage I lung cancer was detected (OR 4.464, 95%CI 2.860 - 6.969) by LDCT. Moreover, LDCT screening showed an increased detection of adenocarcinoma in lung cancer (OR 4.652, 95%CI 2.877 - 7.522).

CONCLUSION

LDCT is superior to CXR in the early detection of lung cancer, especially stage I and adenocarcinoma.

摘要

目的

通过对相关文献的荟萃分析，探讨低剂量计算机断层扫描（LDCT）在早期肺癌高危人群筛查中的价值。

方法

以关键词检索PubMed、EBSCO、Cochrane等数据库。并根据纳入和排除标准筛选研究。采用统计软件收集并分析基线数据。

结果

选取了10项随机对照试验（RCT）。与胸部X线（CXR）筛查和未筛查对照组相比，LDCT筛查的优势比（OR）为3.705，95%置信区间（CI）为3.527 - 3.891。在亚组分析中，LDCT检测到的I期肺癌数量更多（OR 4.464，95%CI 2.860 - 6.969）。此外，LDCT筛查显示肺癌中腺癌的检出率增加（OR 4.652，95%CI 2.877 - 7.522）。