Department of Ophthalmology & Vision Sciences, University of Toronto, Toronto, Ont.
Can J Ophthalmol. 2012 Feb;47(1):51-4. doi: 10.1016/j.jcjo.2011.12.012.
Central corneal thickness (CCT) affects intraocular pressure (IOP) readings; however, CCT influence on topical medication efficacy is unknown. We evaluated the IOP-lowering effect of topical prostaglandin analogues (PGAs) in relation to CCT.
Post hoc analysis of a randomized prospective trial.
Subjects randomized to a PGA were followed for 24 weeks and were analyzed for relationship between CCT and IOP lowering.
Patients with either newly diagnosed ocular hypertension or open-angle glaucoma.
75 subjects were enrolled. The mean age was 62.7 ± 10.5 years; 48 were Caucasian. The mean CCT was 562.4 ± 41.4 μ. At repeated measures, ANCOVA analysis showed a significant effect of both baseline IOP (p < 0.0001) and CCT (p = 0.003) on IOP. At week 12, a regression analysis of the effect of CCT on baseline IOP showed that for every 10 μ increase in CCT there was 0.3 mm Hg less IOP decrease from baseline.
We found a statistically significantly association between a lower mean IOP and a thinner cornea when baseline IOP is controlled for. The magnitude of the relationship is small but may be clinically significant in patients with either very thin or very thick corneas.
中央角膜厚度（CCT）会影响眼内压（IOP）读数；然而，CCT 对局部药物疗效的影响尚不清楚。我们评估了与 CCT 相关的局部前列腺素类似物（PGAs）的降眼压效果。
随机前瞻性试验的事后分析。
随机分配到 PGA 的受试者随访 24 周，并分析 CCT 与眼压降低之间的关系。
新诊断的高眼压或开角型青光眼患者。
共纳入 75 例受试者。平均年龄为 62.7 ± 10.5 岁；48 例为白种人。平均 CCT 为 562.4 ± 41.4 μ。在重复测量的 ANCOVA 分析中，基线 IOP（p < 0.0001）和 CCT（p = 0.003）对 IOP 均有显著影响。在第 12 周，对 CCT 对基线 IOP 的影响进行回归分析表明，CCT 每增加 10 μ，基线 IOP 降低 0.3 mmHg。
在控制基线 IOP 的情况下，我们发现平均眼压较低与角膜较薄之间存在统计学显著关联。这种关系的幅度虽然较小，但在角膜非常薄或非常厚的患者中可能具有临床意义。
