University of Michigan, Cell and Molecular Biology Program, United States.
Cancer Lett. 2012 Sep 1;322(1):1-7. doi: 10.1016/j.canlet.2012.02.002. Epub 2012 Feb 11.
Cancer stem cells are rare chemotherapy resistant cells within a tumor which can serve to populate the bulk of a tumor with more differentiated daughter cells and potentially contribute to recurrent disease. Ovarian cancer is a disease for which at the time of initial treatment we can obtain complete clinical remission in the majority of patients. Unfortunately, most will relapse and succumb to their disease. This clinical course is in line with the cancer stem cell model. In the past 5 years a significant amount of work has been done to identify cells with characteristics of ovarian cancer stem cells. This review will focus specifically on the markers used to define human ovarian cancer stem cells, the prognostic implications of the expression of these cancer stem cell markers in patient's primary tumors, and the potential of these cancer stem cell markers to serve as therapeutic targets.
癌症干细胞是肿瘤内罕见的化疗耐药细胞，它们可以产生更多分化的子细胞来填充肿瘤，并可能导致疾病复发。卵巢癌是一种在初始治疗时，我们可以使大多数患者获得完全临床缓解的疾病。不幸的是，大多数患者会复发并死于疾病。这种临床病程与癌症干细胞模型一致。在过去的 5 年中，已经做了大量的工作来鉴定具有卵巢癌干细胞特征的细胞。这篇综述将特别关注用于定义人类卵巢癌干细胞的标志物、这些癌症干细胞标志物在患者原发性肿瘤中的表达的预后意义，以及这些癌症干细胞标志物作为治疗靶点的潜力。
