Clements Ian P, Akerem Khan Shamruz Khan, Chen Horng H, Mullan Brian P
Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA.
Nucl Med Commun. 2012 May;33(5):481-5. doi: 10.1097/MNM.0b013e32835167ae.
We previously developed an operator-interactive method for the measurement of left ventricular (LV) and right ventricular (RV) ejection fraction (EF) and end-systolic volume (ESV) and end-diastolic volume (EDV) using single-photon emission tomographic equilibrium radionuclide angiocardiography (SPECT ERNA). We aimed to compare our SPECT ERNA method with cardiac MRI (CMRI) for the determination of ventricular measures.
Paired measurements of LV and RV EFs and ESV and EDV were carried out by SPECT ERNA and CMRI in a group of patients who had myocardial infarction due to left anterior descending coronary artery thrombosis.
SPECT ERNA and CMRI provided similar estimations of the mean (SD) LV ESV [61 (23) vs. 61 (32) ml; P=0.99] and LV EDV [134 (29) vs. 141 (44) ml; P=0.28]. The mean (SD) LV EF by SPECT ERNA was slightly but significantly smaller than that by CMRI [0.55 (0.10) vs. 0.58 (0.11) ml; P=0.03]. SPECT ERNA, compared with CMRI, produced similar mean (SD) values of RV ESV [62 (17) vs. 67 (17) ml; P=0.10] and RV EDV [153 (28) vs. 149 (29) ml; P=0.51] and somewhat larger mean (SD) RV EF [0.60 (0.06) vs. 0.55 (0.06) ml; P<0.001]. Excellent correlations were found between SPECT ERNA and CMRI for combined LV ESV and EDV (R=0.85, P<0.001) and combined RV ESV and EDV (R=0.85, P<0.001).
This study further validates SPECT ERNA as a method to measure LV and RV EF, ESV, and EDV.
我们之前开发了一种操作员交互式方法，用于使用单光子发射断层扫描平衡放射性核素血管造影术（SPECT ERNA）测量左心室（LV）和右心室（RV）射血分数（EF）、收缩末期容积（ESV）和舒张末期容积（EDV）。我们旨在比较我们的SPECT ERNA方法与心脏磁共振成像（CMRI）在测定心室指标方面的差异。
对一组因左前降支冠状动脉血栓形成而发生心肌梗死的患者，采用SPECT ERNA和CMRI对LV和RV的EF、ESV及EDV进行配对测量。
SPECT ERNA和CMRI对LV平均（标准差）ESV的估计相似[61（23）对61（32）ml；P = 0.99]，对LV EDV的估计也相似[134（29）对141（44）ml；P = 0.28]。SPECT ERNA测得的LV平均（标准差）EF略低于CMRI，但差异有统计学意义[0.55（0.10）对0.58（0.11）ml；P = 0.03]。与CMRI相比，SPECT ERNA测得的RV平均（标准差）ESV[62（17）对67（17）ml；P = 0.10]和RV EDV[153（28）对149（29）ml；P = 0.51]相似，而RV平均（标准差）EF略高[0.60（0.06）对0.55（0.06）ml；P < 0.001]。SPECT ERNA与CMRI在联合LV ESV和EDV（R = 0.85，P < 0.001）以及联合RV ESV和EDV（R = 0.85，P < 0.001）方面具有极好的相关性。
本研究进一步验证了SPECT ERNA作为测量LV和RV EF、ESV及EDV的一种方法。
