Sauer B, Staritz M
Klinik für Innere Medizin I, Schwarzwald-Baar-Klinikum Villingen-Schwenningen GmbH.
Dtsch Med Wochenschr. 2012 Feb;137(8):368-70. doi: 10.1055/s-0031-1298951. Epub 2012 Feb 14.
A 58-year-old man was admitted for elucidation of a microcytic anemia diagnosed by his general practitioner (hemoglobin of 5,5 g/dl). He felt dizzy and unwell. The patient had for some time been regularly taking 1-2 tablets of diclofenac, a nonsteroid anti-inflammatory drug (NSAID), for joint and gouty pain. He had occasionally noted small amounts of blood on his stool. The physical examination was unremarkable except for obesity, several swollen and painful joints, and a gouty right big toe with a tophus and small ulcer.
Coloscopy revealed extensive multiple aphthous ulcers throughout the colon (histologically diagnosed as NSAID colopathy). Esophagogastroduodenoscopy failed to identify a source of bleeding. But it also revealed a double pylorus, which was divided into two equal parts by a smooth, pencil-thick circular band, but fully patent and without inflammatory changes or scarring.
Several erythrocyte units were infused, which stabilized the patient's condition. There was no evidence of renewed bleeding. But subsequently he experienced severe joint pain, the CPR rising to 252.31 mg/dl. Administration of steroids, novaminsulfon and opioids, as well as uric acid lowering drugs gradually improved the joint pain and enabled physiotherapy to improve mobility and the patient was discharged home.
Congenital abnormalities are rarely found during gastrointestinal endoscopy in adults. Very rare are duplications of the pyloric channel most of which are acquired by ulcer perforation. In general, congenital double pylorus is mainly a harmless incidental finding which needs no therapy, but it should be distinguished from acquired double pylorus. Endoscopists should be aware of this abnormality to avoid complications during side-view endoscopy.
一名58岁男性因全科医生诊断出的小细胞性贫血(血红蛋白5.5g/dl)入院以明确病因。他感到头晕不适。该患者有一段时间一直定期服用1 - 2片双氯芬酸(一种非甾体抗炎药)来缓解关节和痛风疼痛。他偶尔注意到大便上有少量血迹。体格检查除肥胖、多个关节肿胀疼痛以及右大脚趾痛风伴痛风石和小溃疡外无异常。
结肠镜检查显示整个结肠有广泛的多发性阿弗他溃疡(组织学诊断为非甾体抗炎药结肠病)。食管胃十二指肠镜检查未发现出血源。但检查还发现了双幽门,它被一条光滑的铅笔粗细的环形带分成两个相等部分,但完全通畅且无炎症改变或瘢痕形成。
输注了几个红细胞单位,使患者病情稳定。没有再次出血的迹象。但随后他经历了严重的关节疼痛,CPR升至252.31mg/dl。使用类固醇、新维生素磺酸钠和阿片类药物以及降尿酸药物后,关节疼痛逐渐改善,使物理治疗能够改善活动能力,患者随后出院回家。
先天性异常在成人胃肠道内镜检查中很少见。幽门管重复畸形非常罕见,其中大多数是由溃疡穿孔引起的。一般来说,先天性双幽门主要是一种无害的偶然发现,无需治疗,但应与后天性双幽门相区分。内镜医师应了解这种异常情况,以避免侧视内镜检查期间出现并发症。