Department of Endocrinology-Endocrine Oncology, Theagenion Cancer Hospital, Thessaloniki, Greece.
Horm Metab Res. 2012 Apr;44(4):255-62. doi: 10.1055/s-0031-1299741. Epub 2012 Feb 14.
Thyroid cancer can be associated with thyrotoxicosis caused by Graves' disease, toxic multinodular goiter, or autonomously functioning thyroid adenoma. The objective of this study was to summarize current evidence regarding the association of thyroid cancer and hyperthyroidism, particularly with respect to the type of hyperthyroidism found in some patients, and whether this affects the outcome of the patient. A PubMed search was performed up to August 2011. Articles were identified using combinations of the following keywords/phrases: thyroid cancer, papillary thyroid cancer, follicular thyroid cancer, medullary thyroid cancer, anaplastic thyroid cancer, hyperthyroidism, Graves' disease, auto-nomous adenoma, toxic thyroid nodule, and toxic multinodular goiter. Original research papers, case reports, and review articles were included. We concluded that the incidence, as well as the prognosis of thyroid cancer associated with hyperthyroidism is a matter of debate. It seems that Graves' disease is associated with larger, multifocal, and potentially more aggressive thyroid cancer than single hot nodules or multinodular toxic goiter. Patients with Graves' and thyroid nodules are at higher risk to develop thyroid cancer compared to patients with diffuse goiter. Every suspicious nodule associated with hyperthyroidism should be evaluated carefully.
甲状腺癌可与由格雷夫斯病、毒性多结节性甲状腺肿或自主功能性甲状腺腺瘤引起的甲状腺毒症相关。本研究的目的是总结目前关于甲状腺癌与甲状腺毒症关联的证据，特别是关于一些患者中发现的甲状腺毒症类型，以及这是否影响患者的预后。截至 2011 年 8 月，进行了一次 PubMed 检索。使用以下关键词/词组的组合来确定文章：甲状腺癌、甲状腺乳头状癌、甲状腺滤泡癌、甲状腺髓样癌、间变性甲状腺癌、甲状腺毒症、格雷夫斯病、自主腺瘤、毒性甲状腺结节、毒性多结节性甲状腺肿。纳入了原始研究论文、病例报告和综述文章。我们得出结论，与甲状腺毒症相关的甲状腺癌的发病率以及预后仍存在争议。似乎格雷夫斯病与更大、多灶性和潜在侵袭性更强的甲状腺癌相关，而不是单个热结节或多结节毒性甲状腺肿。与弥漫性甲状腺肿相比，患有格雷夫斯病和甲状腺结节的患者发生甲状腺癌的风险更高。与甲状腺毒症相关的每个可疑结节都应仔细评估。
