Bulut Ipek Kaplan, Mir Sevgi, Sozeri Betul, Bulut Mustafa Orhan, Sen Sait, Dincel Nida
Ege University Faculty of Medicine Department of Pediatric Nephrology, Izmir.
Int J Nephrol Renovasc Dis. 2012;5:23-8. doi: 10.2147/IJNRD.S24684. Epub 2012 Jan 20.
Immunoglobulin A nephropathy (IgAN) is the most common primary glomerulonephritis. Patients manifest variable clinical symptoms (eg, microhematuria) with preserved or progressive deterioration of renal function resulting in end-stage renal disease. The aim of this study was to evaluate patients from a single center to describe the clinical features, treatments, and follow-up results of those with the disease.
This is a retrospective data study of all children with IgAN. Patients who had a histopathologically proven diagnosis of IgAN and were followed up for at least 5 years were included in the study. Renal biopsy, graded as Hass classification, was performed on all patients. A total of 39 patients were included in the study.
The mean follow-up time (± standard deviation) was 10.4 ± 3.51 (range 5-16) years. Twenty-nine patients (74.4%) were male and ten (25.6%) were female. Nineteen (48.7%) patients presented with recurrent macroscopic hematuria, ten (25.6%) with microscopic hematuria ± proteinuria, six (15.4%) with nephritic syndrome, and four (10.3%) with nephrotic syndrome. All patients underwent a renal biopsy, which was graded according to the Hass classification. At the end of follow-up time, 18 (46.1%) patients were normal, 15 (38.5%) had minor urinary abnormalities, three (7.7%) had active renal disease, and three (7.7%) developed renal failure.
The results of the present study are better than those from most other series. The majority of children with IgAN in this study were admitted with recurrent macroscopic hematuria and found to have a good prognosis. We suggest that children with IgAN have a good prognosis in the first 5-year follow-up period.
免疫球蛋白A肾病（IgAN）是最常见的原发性肾小球肾炎。患者表现出不同的临床症状（如镜下血尿），肾功能可保持正常或进行性恶化，最终导致终末期肾病。本研究的目的是评估来自单一中心的患者，以描述该疾病患者的临床特征、治疗方法和随访结果。
这是一项对所有IgAN儿童患者的回顾性数据研究。纳入研究的患者需经组织病理学确诊为IgAN且随访至少5年。所有患者均进行了肾活检，并按照Hass分级法进行分级。本研究共纳入39例患者。
平均随访时间（±标准差）为10.4±3.51年（范围5 - 16年）。29例（74.4%）为男性，10例（25.6%）为女性。19例（48.7%）患者表现为反复肉眼血尿，10例（25.6%）为镜下血尿±蛋白尿，6例（15.4%）为肾炎综合征，4例（10.3%）为肾病综合征。所有患者均接受了肾活检，并根据Hass分级法进行分级。随访结束时，18例（46.1%）患者肾功能正常，15例（38.5%）有轻微尿液异常，3例（7.7%）有活动性肾脏疾病，3例（7.7%）发展为肾衰竭。
本研究结果优于大多数其他系列研究。本研究中大多数IgAN儿童患者以反复肉眼血尿入院，且预后良好。我们认为IgAN儿童患者在最初5年随访期内预后良好。
