Noël Delphine, Landais Paul
Service de biostatistique et d'informatique médicale, hôpital Necker-Enfants Malades, AP-HP, UPRES EA 4472 NAMADES, université Paris-Descartes, faculté de médecine.
Rev Prat. 2012 Jan;62(1):38-42.
Chronic kidney disease (CKD) is set in 5 stages of increasing severity with a decrease in glomerular filtration rate leading to end stage renal disease (ESRD) requiring a treatment of substitution, dialysis or transplantation. CKD is frequent, it increases with age, and affects one person out of 10 in the general population, and only 4 per 100,000 will reach end-stage renal disease (ESRD). As soon as it occurs, CKD is associated with increased cardiovascular comorbid conditions. Mortality in dialysis is far higher than in the general population. In France, more than 4 billion Euros per year, i.e. 2% of the overall health expenditures, are dedicated to the treatment of 0.11% of the population. It is, therefore at the early stages of CKD that the efforts of screening and prevention of ESRD should be targeted.
慢性肾脏病（CKD）分为5个严重程度递增的阶段，随着肾小球滤过率下降，最终发展为终末期肾病（ESRD），需要进行替代治疗、透析或移植。CKD很常见，其发病率随年龄增长而升高，普通人群中每10人就有1人受影响，而每10万人中只有4人会发展为终末期肾病（ESRD）。CKD一旦发生，就会伴有心血管合并症增加。透析患者的死亡率远高于普通人群。在法国，每年有超过40亿欧元，即占医疗卫生总支出的2%，用于治疗仅占人口0.11%的患者。因此，ESRD的筛查和预防工作应着眼于CKD的早期阶段。
