Birkhäuser M, Riondel A, Vallotton M B
Acta Endocrinol (Copenh). 1979 Jun;91(2):294-302. doi: 10.1530/acta.0.0910294.
The influence of the dopaminergic agent 2-bromoergocryptine on plasma aldosterone response to acute stimulations was assessed in 14 normal male volunteers. Without modifying basal plasma aldosterone levels or urinary aldosterone excretion, bromocriptine retarded and diminished significantly the plasma aldosterone response to angiotensin II or ACTH, but did not alter the response to upright posture. These results point to a bromocriptine-induced modulation of the plasma aldosterone response to direct stimulations at the adrenal level. The present work brings further evidence for an effect of the dopaminergic system on the physiological control of aldosterone.
在14名正常男性志愿者中评估了多巴胺能药物2-溴麦角隐亭对血浆醛固酮急性刺激反应的影响。溴隐亭在不改变基础血浆醛固酮水平或尿醛固酮排泄的情况下，显著延迟并减弱了血浆醛固酮对血管紧张素II或促肾上腺皮质激素的反应，但未改变对直立姿势的反应。这些结果表明，溴隐亭可诱导血浆醛固酮对肾上腺水平直接刺激的反应发生调节。本研究为多巴胺能系统对醛固酮生理控制的作用提供了进一步的证据。
