Chen Yan, Zheng Yu-hong, Lin Ying-ying, Hu Min-hua, Chen Yan-song
Clinical Laboratory Department, Fujian Medical University Teaching Hospital, Fuzhou, Fujian, China.
Zhonghua Zhong Liu Za Zhi. 2011 Nov;33(11):842-6.
To investigate the clinical and prognostic values of preoperative serum CA153, CEA and TPS levels in patients with primary breast cancer.
A total of 386 hospitalized patients with stage I ∼ IV breast cancer from Nov 1998 to Feb 2009 were followed up, and their clinicopathological data were analyzed retrospectively to determine the factors affecting their prognosis.
First, preoperative serum CA153 expression level was significantly associated with the age of onset and tumor size (P < 0.05), the expression of serum CEA was correlated with tumor size (P < 0.05), and the expression of serum tissue polypeptide specific antigen (TPS) was correlated with tumor size and lymph node metastases (P < 0.05). Second, the overall survival was significantly shorter among patients with elevated serum CA153, CEA or TPS, respectively (P < 0.05 for overall). Finally, multivariate Cox regression analysis indicated that estrogen receptor status (ER) and elevated preoperative values of CA 153 are independent prognostic factors for overall survival (P < 0.05), and CA 153 is a risk factor but estrogen receptor status is a protective factor for overall survival.
Higher preoperative expression of serum CA153, CEA or TPS is closely correlated with clinicopathological characteristics and overall survival. The prognosis is poorer in primary breast cancer patients with higher CA15-3 expression level, and pre-treatment CA153 expression level can be used as an independent prognostic parameter in patients with primarily breast cancer.
探讨术前血清CA153、CEA及TPS水平在原发性乳腺癌患者中的临床及预后价值。
对1998年11月至2009年2月期间住院的386例Ⅰ～Ⅳ期乳腺癌患者进行随访，并对其临床病理资料进行回顾性分析，以确定影响其预后的因素。
首先，术前血清CA153表达水平与发病年龄及肿瘤大小显著相关（P<0.05），血清CEA表达与肿瘤大小相关（P<0.05），血清组织多肽特异性抗原（TPS）表达与肿瘤大小及淋巴结转移相关（P<0.05）。其次，血清CA153、CEA或TPS升高的患者总体生存期分别显著缩短（总体P<0.05）。最后，多因素Cox回归分析表明，雌激素受体状态（ER）及术前CA153值升高是总体生存的独立预后因素（P<0.05），CA153是总体生存的危险因素，而雌激素受体状态是保护因素。
术前血清CA153、CEA或TPS的高表达与临床病理特征及总体生存密切相关。CA15-3表达水平较高的原发性乳腺癌患者预后较差，术前CA153表达水平可作为原发性乳腺癌患者的独立预后参数。
