Zheng Hang, He Ben-fu, Luo Rong-cheng, You Chang-xuan, Mai Guo-feng, Lu Hui-fang
Department of Oncology, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
Di Yi Jun Yi Da Xue Xue Bao. 2003 Aug;23(8):823-5.
To investigate the expression of serum tissue polypeptide-specific antigen (TPS) in breast cancer patients and its clinical value in such cases.
Altogether 160 subjects (90 patients with breast cancer, 40 with benign breast lesions, and 30 healthy subjects) were enrolled in this study. The serum TPS and CA153 levels were measured by ELISA in all the subjects.
The levels and positivity rate of serum TPS and CA153 in breast cancer group were significantly higher than those in the normal subjects group and benign lesion group (P<0.01), and became even higher as the malignancy progressed. High serum TPS level was detected in the cancer patients in stage I. Serum TPS level was the most sensitive to bone metastasis of the malignancy, but its highest levels occurred in cases of lymphoid node metastasis (P<0.05). In patients who responded favorably to the treatment, serum TPS and CA153 levels were significantly reduced (P<0.05), but the reduction in TPS levels tended to be more obvious (P<0.05).
Serum TPS can be used as a very useful and sensitive tumor marker in the diagnosis of breast cancer, especially in case of bone metastasis, and may be of great value in clinical decision-making and assessment of therapeutic effect.
探讨血清组织多肽特异性抗原（TPS）在乳腺癌患者中的表达及其临床价值。
本研究共纳入160名受试者（90例乳腺癌患者、40例乳腺良性病变患者和30名健康受试者）。采用酶联免疫吸附测定法（ELISA）检测所有受试者血清TPS和CA153水平。
乳腺癌组血清TPS和CA153水平及阳性率显著高于正常对照组和良性病变组（P<0.01），且随着恶性程度进展而升高。I期癌症患者血清TPS水平较高。血清TPS水平对恶性肿瘤骨转移最为敏感，但其最高水平出现在淋巴结转移患者中（P<0.05）。治疗反应良好的患者血清TPS和CA153水平显著降低（P<0.05），但TPS水平降低更明显（P<0.05）。
血清TPS可作为诊断乳腺癌尤其是骨转移的一项非常有用且敏感的肿瘤标志物，在临床决策和疗效评估中可能具有重要价值。
