听觉神经病谱系障碍中8毫秒时的正向波（P8）及改良听觉脑干反应测量
A positive wave at 8 ms (P8) and modified auditory brainstem responses measurement in auditory neuropathy spectrum disorder.
作者信息
Schmidt Claus-Michael, Huebner Jan Robin, Deuster Dirk, Zehnhoff-Dinnesen Antoinette Am, Knief Arne
机构信息
Muenster University Hospital, Department of Phoniatrics and Pedaudiology, Kardinal-von-Galen-Ring 10, 48129 Muenster, Germany.
出版信息
Int J Pediatr Otorhinolaryngol. 2012 May;76(5):636-41. doi: 10.1016/j.ijporl.2012.01.026. Epub 2012 Feb 13.
OBJECTIVE
Auditory neuropathy spectrum disorder (ANSD) is characterized by absent or atypical auditory brainstem responses (ABR), recordable otoacoustic emissions and/or cochlear microphonics. Modification of ABR stimuli is discussed to improve wave V synchronization in ANSD patients.
DESIGN
Ten ANSD children (seven unilateral) underwent ABR measurement with an alternating stimulus (40.5s(-1)), constant rarefaction and condensation stimuli, a reduced click-rate (11.1s(-1)) and a chirp-stimulus.
RESULTS
The results showed no remarkably better synchronization with modified stimuli. Whereas higher levels showed no synchronization, reproducible positive waves at 8 ms (P8) at intensities of 65-85 dB were found in six patients with all stimuli.
CONCLUSIONS
We suggest an ipsilateral auditory origin of the positive potentials at 8 ms. They could be characteristic of synchronization abnormalities in some cases of ANSD.
目的
听觉神经病谱系障碍（ANSD）的特征是听觉脑干反应（ABR）缺失或异常、可记录的耳声发射和/或耳蜗微音电位。本文讨论了ABR刺激的调整方法，以改善ANSD患者的V波同步性。
设计
10名ANSD儿童（7名单侧患病）接受了ABR测量，测量时采用了交替刺激（40.5次/秒）、恒定的疏波和密波刺激、降低的短声频率（11.1次/秒）以及啁啾刺激。
结果
结果显示，调整后的刺激并未显著改善同步性。虽然高强度刺激下未出现同步，但在65 - 85分贝强度时，6名患者在所有刺激下均在8毫秒时出现了可重复的正向波（P8）。
结论
我们认为8毫秒时的正向电位起源于同侧听觉。在某些ANSD病例中，它们可能是同步异常的特征。
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