Centre for Brain and Mental Health Research, Faculty of Health, University of Newcastle, New South Wales, Australia.
Psychol Med. 2012 Oct;42(10):2015-26. doi: 10.1017/S0033291712000128. Epub 2012 Feb 16.
Cross-sectional studies support an association between depression and inflammatory markers. However, little is known of their relationship in the context of antidepressant treatment. Our aim was to explore via meta-analysis whether antidepressant treatment is associated with a reduction in three inflammatory markers associated with depression.
A computerized search of EMBASE, Medline, PsycINFO and Cochrane Library databases was completed using subject headings for depression and either interleukin-6, C-reactive protein or interleukin-10, selecting studies which reported circulating levels of inflammatory markers before and after antidepressant treatment for people with depression. Outcome and moderator variables were coded for analysis, including inflammatory marker change, depression severity change, age, gender ratio, assay brand, treatment response and weight change.
Pooled effect sizes showed a significant decrease in interleukin-6 (n=14, d=-0.42, p=0.02), marginally significant decrease in C-reactive protein (n=8, d=-0.57, p=0.05) and a non-significant decrease in interleukin-10 (n=3, d=-0.45, p=0.14) after treatment. High levels of heterogeneity were observed, which may be associated with clinical variations between the studies such as weight gain, anxiety, incomplete remission and other individual differences and co-morbidities.
The findings of this meta-analysis indicate that there may be a normalization of overactive inflammatory processes following antidepressant treatment.
横断面研究支持抑郁与炎症标志物之间存在关联。然而，在抗抑郁治疗的背景下，人们对它们之间的关系知之甚少。我们的目的是通过荟萃分析来探讨抗抑郁治疗是否与三种与抑郁相关的炎症标志物的降低有关。
使用抑郁和白细胞介素-6、C 反应蛋白或白细胞介素-10 的主题词，对 EMBASE、Medline、PsycINFO 和 Cochrane Library 数据库进行计算机检索，选择报告抗抑郁治疗前后抑郁患者循环炎症标志物水平的研究。对结局和调节变量进行编码分析，包括炎症标志物变化、抑郁严重程度变化、年龄、性别比、检测品牌、治疗反应和体重变化。
汇总的效应大小显示白细胞介素-6（n=14，d=-0.42，p=0.02）显著降低，C 反应蛋白（n=8，d=-0.57，p=0.05）略有降低，白细胞介素-10（n=3，d=-0.45，p=0.14）在治疗后无显著降低。观察到高度的异质性，这可能与研究之间的临床差异有关，如体重增加、焦虑、不完全缓解和其他个体差异和合并症。
本荟萃分析的结果表明，抗抑郁治疗后，过度活跃的炎症过程可能会恢复正常。
