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细菌病原体李斯特菌的非编码 RNA 世界。

The non-coding RNA world of the bacterial pathogen Listeria monocytogenes.

机构信息

Institut Pasteur, Unité des Interactions Bactéries-Cellules, Paris, France.

出版信息

RNA Biol. 2012 Apr;9(4):372-8. doi: 10.4161/rna.19235. Epub 2012 Feb 16.

Abstract

In the past ten years, Listeria monocytogenes has emerged as a model organism in infection biology and also become an attractive system for the study of regulatory RNAs in pathogenic bacteria. Due to the recent completion of several transcriptomic studies, it is now clear that L. monocytogenes possesses a large repertoire of both cis- and trans-encoded RNAs. These include numerous small RNAs (sRNAs) expressed during infection, widespread transcription of both short and long antisense RNAs (asRNAs) and an array of cis-acting regulatory RNA elements. In this review we highlight the recent advances in non-coding RNA research in L. monocytogenes with a particular focus on emerging themes of RNA-based regulation.

摘要

在过去的十年中,李斯特菌已成为感染生物学的模式生物,同时也成为研究致病菌调控 RNA 的有吸引力的系统。由于最近完成了几项转录组研究,现在很清楚李斯特菌拥有大量的顺式和反式编码 RNA。这些包括在感染过程中表达的许多小 RNA(sRNA)、短和长反义 RNA(asRNA)的广泛转录以及一系列顺式作用调节 RNA 元件。在这篇综述中,我们重点介绍了李斯特菌中非编码 RNA 研究的最新进展,特别关注基于 RNA 的调控的新兴主题。

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