Renal Unit, King's College Hospital, London, UK.
Kidney Int. 2012 Apr;81(8):727-32. doi: 10.1038/ki.2011.500. Epub 2012 Feb 15.
Antibody-mediated pure red cell aplasia is a very rare but devastating condition affecting patients receiving treatment with erythropoiesis-stimulating agents. New cases continue to emerge, generally in clusters, consistent with an 'environmental' trigger to its pathogenesis. Defining the causes of antibody-mediated pure red cell aplasia is clearly of importance for patients with chronic kidney disease, but any developments in this area may also have relevance to other disease areas as therapeutic delivery of endogenous proteins rapidly increases. This review focuses on the current knowledge regarding the etiology of antibody-mediated pure red cell aplasia and the current approach to therapy.
抗体介导的纯红细胞再生障碍性贫血是一种非常罕见但却具有破坏性的疾病，会影响接受促红细胞生成素治疗的患者。新的病例不断出现，通常呈簇状，与发病机制的“环境”触发因素一致。明确抗体介导的纯红细胞再生障碍性贫血的病因对慢性肾脏病患者显然很重要，但该领域的任何进展也可能与其他疾病领域相关，因为内源性蛋白的治疗性输送正在迅速增加。这篇综述重点介绍了抗体介导的纯红细胞再生障碍性贫血的病因学和当前治疗方法的最新知识。
