Padhi Somanath, Behera Gayatri, Pattnaik Sandeep Abhijit, Das Prabodh Kumar, Adhya Amit Kumar, Patra Susama
Department of Pathology and Laboratory Medicine, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Department of Medical Oncology/Hematology, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.
Indian J Nephrol. 2020 Mar-Apr;30(2):113-116. doi: 10.4103/ijn.IJN_129_19. Epub 2019 Sep 6.
Acquired pure red cell aplasia (PRCA) following use of recombinant erythropoietin (rEPO) is distinctly rare and sporadically reported in the literature. We discuss a case of PRCA following the usage of rEPO (darbepoetin-α) during the management of anemia of chronic kidney disease in an elderly male subject with review of literature and a brief insight into proposed pathophysiologic mechanism, diagnosis, and management.
使用重组促红细胞生成素（rEPO）后获得性纯红细胞再生障碍性贫血（PRCA）极为罕见，文献中仅有零星报道。我们讨论了一例老年男性患者在慢性肾脏病贫血管理期间使用rEPO（达贝泊汀-α）后发生PRCA的病例，并回顾了文献，简要探讨了可能的病理生理机制、诊断及管理方法。
