Department of Pulmonary Medicine, Christian Medical College, Vellore 632002, Tamil Nadu, India.
Singapore Med J. 2012 Feb;53(2):e32-4.
Pulmonary cryptococcosis presenting as an endobronchial tumour-like growth has rarely been described. We report the case of a male patient with normal immune function who presented with a right upper lobe mass lesion. Bronchoscopy revealed a tumour-like growth that completely occluded the anterior segment of the right upper lobe bronchus. Bronchial biopsy and computed tomography-guided lung biopsy revealed Cryptococcus, and culture of lung biopsy specimen grew Cryptococcus neoformans and Mycobacterium tuberculosis. The patient responded clinically to amphotericin B, fluconazole and anti-tuberculous therapy. However, chest radiographic response was unremarkable. A presentation of pulmonary cryptococcosis and tuberculosis, along with endobronchial tumour-like growth in the same patient, is unusual and has not been previously described.
肺部隐球菌病表现为支气管内肿瘤样生长的情况很少见。我们报告了一例免疫功能正常的男性患者，其表现为右上肺肿块病变。支气管镜检查显示肿瘤样生长，完全阻塞右上叶支气管前段。支气管活检和 CT 引导下肺活检显示隐球菌，肺活检标本培养出新型隐球菌和结核分枝杆菌。该患者对两性霉素 B、氟康唑和抗结核治疗有临床反应。然而，胸部 X 线反应无明显变化。肺部隐球菌病和肺结核同时出现，并伴有支气管内肿瘤样生长在同一患者中并不常见，以前也没有描述过。
