Kahn F W, England D M, Jones J M
Am J Med. 1985 Apr;78(4):677-81. doi: 10.1016/0002-9343(85)90413-9.
This report describes a rare combined infection of Cryptococcus neoformans and Mycobacterium tuberculosis that manifested as a solitary pulmonary nodule in a nonimmunocompromised patient. Transthoracic needle aspiration biopsy was initially nondiagnostic, and histopathologic and culture confirmation of the diagnosis was eventually attained after wedge resection of the nodule. An extensive review of the English literature failed to reveal any reported cases of such a combined infection with a similar clinical presentation. The variable morphologic features of C. neoformans in tissue sections and the protean histologic features of pulmonary cryptococcosis can lead to diagnostic difficulties, as illustrated by this case.
本报告描述了一例罕见的新型隐球菌与结核分枝杆菌合并感染病例，该病例表现为一名非免疫功能低下患者的孤立性肺结节。经胸针吸活检最初未能明确诊断，最终在对该结节进行楔形切除后，通过组织病理学和培养确诊。广泛查阅英文文献未发现任何有类似临床表现的此类合并感染的报道病例。如本病例所示，组织切片中新型隐球菌形态特征多样，以及肺隐球菌病多变的组织学特征可导致诊断困难。
