循环内皮细胞表面的晚期糖基化终产物受体（RAGE）表达上调在川崎病中。

Expression of receptor for advanced glycation end products (RAGE) on the surface of circulating endothelial cells is upregulated in Kawasaki disease.

机构信息

Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, China.

出版信息

Pediatr Res. 2012 Jun;71(6):720-4. doi: 10.1038/pr.2012.27. Epub 2012 Feb 15.

DOI:10.1038/pr.2012.27

PMID:22337222

Abstract

INTRODUCTION

The aim of this study was to investigate the expression of receptor for advanced glycation end products (RAGE) on the surface of circulating endothelial cells (CECs) in patients with Kawasaki disease (KD).

METHODS

The positive rate of RAGE on the surface of CECs (CECs-RAGE/CECs) and the fluorescence intensity of RAGE on the surface of CECs (FI-RAGE-CECs) were evaluated in 89 patients with KD in the acute stage (A-KD), subacute stage (SA-KD), or convalescent stage (C-KD).

RESULTS

CECs-RAGE/CECs and the FI-RAGE-CECs increased significantly in patients with KD. The CECs-RAGE/CECs was significantly higher in C-KD patients with coronary artery lesions (CALs) than in those without CALs. The FI-RAGE-CECs level was significantly higher in SA-KD and C-KD patients with CALs than in A-KD patients. In SA-KD and C-KD patients, the CECs-RAGE/CECs and FI-RAGE-CECs levels decreased in intravenous immunoglobulin (IVIG)-respondent patients but increased progressively in IVIG-resistant patients and were significantly higher in IVIG-resistant patients than in IVIG-respondent patients.

DISCUSSION

The results suggest that the expression levels of RAGE on the surface of CECs are upregulated in KD patients, and that the upregulated expression levels of RAGE on the surface of CECs can be aggravated in SA-KD and C-KD patients with CALs, and also in IVIG-resistant SA-KD and C-KD patients. The RAGE expression on CECs is involved in the pathophysiology of KD.

摘要

简介

本研究旨在探讨血管紧张素受体（RAGE）在川崎病（KD）患者循环内皮细胞（CECs）表面的表达。

方法

评估 89 例川崎病急性期（A-KD）、亚急性期（SA-KD）和恢复期（C-KD）患者的 CECs 表面 RAGE 阳性率（CECs-RAGE/CECs）和 CECs 表面 RAGE 荧光强度（FI-RAGE-CECs）。

结果

KD 患者的 CECs-RAGE/CECs 和 FI-RAGE-CECs 显著增加。C-KD 合并冠状动脉瘤（CAL）患者的 CECs-RAGE/CECs 明显高于无 CAL 患者。SA-KD 和 C-KD 合并 CAL 患者的 FI-RAGE-CECs 水平明显高于 A-KD 患者。在 SA-KD 和 C-KD 患者中，静脉注射免疫球蛋白（IVIG）反应患者的 CECs-RAGE/CECs 和 FI-RAGE-CECs 水平降低，但 IVIG 耐药患者的水平逐渐升高，且 IVIG 耐药患者明显高于 IVIG 反应患者。