Qi Yanqi, Gong Fangqi, Zhang Qing, Xie Chunhong, Wang Wei, Fu Songling
Arthritis Res Ther. 2012 Nov 21;14(6):R251. doi: 10.1186/ar4094.
Kawasaki disease (KD), an acute febrile disease, characterized by systemic vasculitis, predominantly affects infants and children under 5 years of age. Coronary artery lesions (CALs) are its most critical complication, and the etiology remains unknown yet. In order to explore the value of resistin, S100A12 and soluble receptor for advanced glycation end products (sRAGE) in the pathophysiology of KD, we studied the serum levels of resistin, S100A12 and sRAGE in different stages of KD.
Serum levels of resistin, S100A12 and sRAGE were measured by enzyme-linked immunosorbent assay (ELISA) method in 15 healthy children and 40 KD patients at acute, afebrile and subacute stage.
The resistin and S100A12 levels, including the ratio of resistin to sRAGE and S100A12 to sRAGE increased significantly in the acute stage, and decreased progressively in the afebrile and subacute stage. However, the sRAGE levels decreased significantly in the acute stage, and increased progressively in the afebrile and subacute stage. In the acute, afebrile and subacute stage, the resistin levels were higher in intravenous immunoglobulin (IVIG) non-responders (0.64 ± 0.30, 0.48 ± 0.35, 0.28 ± 0.19, × 102 ng/ml) than in IVIG responders (0.35 ± 0.24, 0.21 ± 0.19, 0.12 ± 0.05, × 102 ng/ml). In the acute and subacute stage, the S100A12 levels were higher in IVIG non-responders (7.92 ± 2.61, 4.98 ± 4.75, × 102 ng/ml) than in IVIG responders (5.05 ± 3.22, 2.35 ± 2.26, × 102 ng/ml). In the afebrile and subacute stage, the sRAGE levels were lower in IVIG non-responders (3.51 ± 2.64, 3.65 ± 3.27, × 102 pg/ml) than in IVIG responders (6.00 ± 2.78, 7.19 ± 2.88, × 102 pg/ml). The resistin levels were positively correlated with S100A12 levels. The sRAGE levels were negatively related with S100A12 and resistin levels.
Resistin, S100A12 and sRAGE are involved in the pathophysiology of KD.
川崎病（KD）是一种急性发热性疾病，其特征为全身性血管炎，主要影响5岁以下的婴幼儿。冠状动脉病变（CALs）是其最严重的并发症，病因尚不明确。为探讨抵抗素、S100A12和晚期糖基化终末产物可溶性受体（sRAGE）在KD病理生理学中的作用，我们研究了KD不同阶段抵抗素、S100A12和sRAGE的血清水平。
采用酶联免疫吸附测定（ELISA）法检测15例健康儿童及40例处于急性期、热退期和亚急性期的KD患儿血清中抵抗素、S100A12和sRAGE的水平。
急性期抵抗素和S100A12水平，包括抵抗素与sRAGE的比值以及S100A12与sRAGE的比值显著升高，在热退期和亚急性期逐渐降低。然而，sRAGE水平在急性期显著降低，在热退期和亚急性期逐渐升高。在急性期、热退期和亚急性期，静脉注射免疫球蛋白（IVIG）无反应者的抵抗素水平（0.64±0.30、0.48±0.35、0.28±0.19，×102 ng/ml）高于IVIG有反应者（0.35±0.24、0.21±0.19、0.12±0.05，×102 ng/ml）。在急性期和亚急性期，IVIG无反应者的S100A12水平（7.92±2.61、4.98±4.75，×102 ng/ml）高于IVIG有反应者（5.05±3.22、2.35±2.26，×102 ng/ml）。在热退期和亚急性期，IVIG无反应者的sRAGE水平（3.51±2.64、3.65±3.27，×102 pg/ml）低于IVIG有反应者（6.00±2.78、7.19±2.88，×102 pg/ml）。抵抗素水平与S100A12水平呈正相关。sRAGE水平与S100A12和抵抗素水平呈负相关。
抵抗素、S100A12和sRAGE参与了KD的病理生理过程。
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