雌激素相关肿瘤表型：¹⁸F-FDG 和 ¹⁸F-FES 的正电子发射断层扫描特征。
Oestrogen-related tumour phenotype: positron emission tomography characterisation with ¹⁸F-FDG and ¹⁸F-FES.
机构信息
Biomedical Imaging Research Center, University of Fukui, Fukui, Japan, University of Fukui, Fukui, Japan.
出版信息
Br J Radiol. 2012 Jul;85(1015):1020-4. doi: 10.1259/bjr/26645378. Epub 2012 Feb 14.
Abstract
This article outlines the role of 16α-[(18)F]fluoro-17β-oestradiol ((18)F-FES) positron emission tomography (PET) combined with 2-[(18)F]fluoro-2-deoxy-D-glucose ((18)F-FDG) in patients with oestrogen-related tumours for evaluating tumour phenotype. (18)F-FES-PET combined with (18)F-FDG is helpful in characterising the distinct phenotypic features of oestrogen-related tumours; that is, inter- and intrapatient tumour heterogeneity, which indicates its great potential as a determinant of individualised treatment and a prognostic predictor for patients with oestrogen-related tumours.
摘要
本文概述了 16α-[(18)F]氟-17β-雌二醇((18)F-FES)正电子发射断层扫描(PET)与 2-[(18)F]氟-2-脱氧-D-葡萄糖((18)F-FDG)联合应用于雌激素相关肿瘤患者，以评估肿瘤表型的作用。(18)F-FES-PET 与 (18)F-FDG 联合有助于描述雌激素相关肿瘤的独特表型特征；即，肿瘤的患者内和患者间异质性，这表明其作为个体化治疗决定因素和雌激素相关肿瘤患者预后预测因子具有巨大潜力。
相似文献
1
Oestrogen-related tumour phenotype: positron emission tomography characterisation with ¹⁸F-FDG and ¹⁸F-FES.雌激素相关肿瘤表型：¹⁸F-FDG 和 ¹⁸F-FES 的正电子发射断层扫描特征。
Br J Radiol. 2012 Jul;85(1015):1020-4. doi: 10.1259/bjr/26645378. Epub 2012 Feb 14.
2
Functional oestrogen receptor α imaging in endometrial carcinoma using 16α-[¹⁸F]fluoro-17β-oestradiol PET.利用 16α-[¹⁸F]氟-17β-雌二醇 PET 对子宫内膜癌进行功能性雌激素受体 α 成像。
Eur J Nucl Med Mol Imaging. 2011 Jan;38(1):37-45. doi: 10.1007/s00259-010-1589-8. Epub 2010 Aug 18.
3
Functional images reflect aggressiveness of endometrial carcinoma: estrogen receptor expression combined with 18F-FDG PET.功能影像反映子宫内膜癌的侵袭性：雌激素受体表达与18F-FDG PET联合应用
J Nucl Med. 2009 Oct;50(10):1598-604. doi: 10.2967/jnumed.108.060145. Epub 2009 Sep 16.
4
The value of PET/CT with FES or FDG tracers in metastatic breast cancer: a computer simulation study in ER-positive patients.使用FES或FDG示踪剂的PET/CT在转移性乳腺癌中的价值：一项针对雌激素受体阳性患者的计算机模拟研究
Br J Cancer. 2015 May 12;112(10):1617-25. doi: 10.1038/bjc.2015.138. Epub 2015 Apr 16.
5
Non-F-2-Fluoro-2-Deoxy-d-Glucose PET/Computed Tomography in Gynecologic Oncology: An Overview of Current Status and Future Potential.非F-2-氟-2-脱氧-D-葡萄糖PET/计算机断层扫描在妇科肿瘤学中的应用：现状与未来潜力概述
PET Clin. 2018 Apr;13(2):239-248. doi: 10.1016/j.cpet.2017.11.008.
6
Positron emission tomography with 2-[18F]Fluoro-2-deoxy-D-glucose and 16alpha-[18F]fluoro-17beta-estradiol in breast cancer: correlation with estrogen receptor status and response to systemic therapy.2-[18F]氟-2-脱氧-D-葡萄糖和16α-[18F]氟-17β-雌二醇正电子发射断层扫描在乳腺癌中的应用：与雌激素受体状态及全身治疗反应的相关性
Clin Cancer Res. 1996 Jun;2(6):933-9.
7
Molecular imaging to identify patients with metastatic breast cancer who benefit from endocrine treatment combined with cyclin-dependent kinase inhibition.分子成像技术可识别出受益于内分泌治疗联合细胞周期蛋白依赖性激酶抑制的转移性乳腺癌患者。
Eur J Cancer. 2020 Feb;126:11-20. doi: 10.1016/j.ejca.2019.10.024. Epub 2019 Dec 28.
8
Biological characterisation of breast cancer by means of PET.通过正电子发射断层显像（PET）对乳腺癌进行生物学特征分析。
Eur J Nucl Med Mol Imaging. 2004 Jun;31 Suppl 1:S80-7. doi: 10.1007/s00259-004-1529-6. Epub 2004 May 4.
9
F-FES PET/CT Influences the Staging and Management of Patients with Newly Diagnosed Estrogen Receptor-Positive Breast Cancer: A Retrospective Comparative Study with F-FDG PET/CT.F-FES PET/CT 对新诊断雌激素受体阳性乳腺癌患者分期和管理的影响：与 F-FDG PET/CT 的回顾性对比研究。
Oncologist. 2019 Dec;24(12):e1277-e1285. doi: 10.1634/theoncologist.2019-0096. Epub 2019 Jul 23.
10
Diagnostic accuracy and safety of 16α-[F]fluoro-17β-oestradiol PET-CT for the assessment of oestrogen receptor status in recurrent or metastatic lesions in patients with breast cancer: a prospective cohort study.16α-[F]氟-17β-雌二醇 PET-CT 评估乳腺癌复发或转移病灶中雌激素受体状态的诊断准确性和安全性：一项前瞻性队列研究。
Lancet Oncol. 2019 Apr;20(4):546-555. doi: 10.1016/S1470-2045(18)30936-7. Epub 2019 Mar 4.
本文引用的文献
1
Additional value of 16α-[18F]fluoro-17β-oestradiol PET for differential diagnosis between uterine sarcoma and leiomyoma in patients with positive or equivocal findings on [18F]fluorodeoxyglucose PET.18F 氟脱氧葡萄糖正电子发射断层扫描（18F-FDG PET）阳性或结果不确定的患者中，16α-[18F]氟-17β-雌二醇 PET 对子宫肉瘤和子宫肌瘤的鉴别诊断的附加价值。
Eur J Nucl Med Mol Imaging. 2011 Oct;38(10):1824-31. doi: 10.1007/s00259-011-1851-8. Epub 2011 Jun 8.
2
Correlation of high 18F-FDG uptake to clinical, pathological and biological prognostic factors in breast cancer.乳腺癌中高 18F-FDG 摄取与临床、病理和生物学预后因素的相关性。
Eur J Nucl Med Mol Imaging. 2011 Mar;38(3):426-35. doi: 10.1007/s00259-010-1640-9. Epub 2010 Nov 6.
3
Functional oestrogen receptor α imaging in endometrial carcinoma using 16α-[¹⁸F]fluoro-17β-oestradiol PET.利用 16α-[¹⁸F]氟-17β-雌二醇 PET 对子宫内膜癌进行功能性雌激素受体 α 成像。
Eur J Nucl Med Mol Imaging. 2011 Jan;38(1):37-45. doi: 10.1007/s00259-010-1589-8. Epub 2010 Aug 18.
4
18F-FDG PET of locally invasive breast cancer and association of estrogen receptor status with standardized uptake value: microarray and immunohistochemical analysis.18F-FDG PET 对局部侵袭性乳腺癌的检测及与雌激素受体状态的关系：微阵列和免疫组化分析。
J Nucl Med. 2010 Apr;51(4):543-50. doi: 10.2967/jnumed.108.060459. Epub 2010 Mar 17.
5
The SUVmax of 18F-FDG PET correlates with histological grade in endometrial cancer.18F-FDG PET 的 SUVmax 与子宫内膜癌的组织学分级相关。
Int J Gynecol Cancer. 2010 Jan;20(1):110-5. doi: 10.1111/IGC.0b013e3181c3a288.
6
Molecular imaging of breast cancer.乳腺癌的分子影像学
Breast. 2009 Oct;18 Suppl 3:S66-73. doi: 10.1016/S0960-9776(09)70276-0.
7
Functional images reflect aggressiveness of endometrial carcinoma: estrogen receptor expression combined with 18F-FDG PET.功能影像反映子宫内膜癌的侵袭性：雌激素受体表达与18F-FDG PET联合应用
J Nucl Med. 2009 Oct;50(10):1598-604. doi: 10.2967/jnumed.108.060145. Epub 2009 Sep 16.
8
Imaging tumor phenotype: 1 plus 1 is more than 2.成像肿瘤表型：1加1大于2 。
J Nucl Med. 2009 Oct;50(10):1567-9. doi: 10.2967/jnumed.108.061044. Epub 2009 Sep 16.
9
Role of PET in gynecologic malignancy.PET 在妇科恶性肿瘤中的作用。
Curr Opin Oncol. 2009 Sep;21(5):420-4. doi: 10.1097/CCO.0b013e32832ec63f.
10
PET and PET-CT imaging of gynecological malignancies: present role and future promise.妇科恶性肿瘤的正电子发射断层显像（PET）及PET计算机断层显像（PET-CT）：当前作用与未来前景
Expert Rev Anticancer Ther. 2009 Jan;9(1):75-96. doi: 10.1586/14737140.9.1.75.
Zotero 插件