Department of Gynecologic Oncology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
Int J Gynecol Cancer. 2010 Jan;20(1):110-5. doi: 10.1111/IGC.0b013e3181c3a288.
The objectives of this study were to assess the maximum standardized uptake value (SUVmax) of F-fluorodeoxyglucose (F-FDG) by a primary tumor of endometrial cancer with the use of positron emission tomography/computed tomography (PET/CT) and to assess its association with the clinical importance of the disease.
F-fluorodeoxyglucose PET/CT scan was performed on 44 participants within 2 weeks before surgery. F-fluorodeoxyglucose uptake was quantified by calculating the SUVmax. The distribution of cases that scored positive for each of the biological parameters examined was correlated with the SUVmax of the F-FDG PET/CT and the glucose transporter-1 expression status obtained by immunohistochemistry.
The mean SUVmax of the primary endometrial cancer tumors was 17.6 (range, 3.04-34.74). There were significant correlations between the SUVmax of the primary tumor and the International Federation of Gynecology and Obstetrics (FIGO) grade (P < 0.001), maximum tumor size (P < 0.001), and glucose transporter-1 expression (P < 0.001). Furthermore, multivariate analysis showed that the FIGO grade was most significantly identified as a relation factor of SUVmax (> or =17.6) for endometrial cancer (P = 0.017). The present findings indicate that a significant relationship was seen between the SUVmax and the FIGO grade in endometrial cancer.
We propose that the primary tumor's SUVmax obtained from F-FDG PET/CT may be associated with aggressive biological characteristics in endometrial cancer.
本研究旨在通过正电子发射断层扫描/计算机断层扫描（PET/CT）评估子宫内膜癌原发肿瘤的氟代脱氧葡萄糖（F-FDG）最大标准化摄取值（SUVmax），并评估其与疾病临床重要性的关系。
44 名参与者在手术前 2 周内进行了 F-FDG PET/CT 扫描。通过计算 SUVmax 来量化 F-FDG 的摄取。检查的每个生物学参数中呈阳性的病例分布与 F-FDG PET/CT 的 SUVmax 以及免疫组织化学获得的葡萄糖转运蛋白-1表达状态相关联。
原发性子宫内膜癌肿瘤的平均 SUVmax 为 17.6（范围，3.04-34.74）。原发性肿瘤的 SUVmax 与国际妇产科联合会（FIGO）分级（P < 0.001）、最大肿瘤大小（P < 0.001）和葡萄糖转运蛋白-1表达（P < 0.001）之间存在显著相关性。此外，多变量分析表明，FIGO 分级是子宫内膜癌 SUVmax（≥17.6）的最显著相关因素（P = 0.017）。本研究结果表明，SUVmax 与子宫内膜癌的 FIGO 分级之间存在显著关系。
我们提出，F-FDG PET/CT 获得的原发性肿瘤 SUVmax 可能与子宫内膜癌的侵袭性生物学特征有关。
