序列分型证实，1988 年至 2010 年期间，加拿大的人类李斯特菌病病例和疫情主要由单增李斯特菌优势克隆引起。
Sequence typing confirms that a predominant Listeria monocytogenes clone caused human listeriosis cases and outbreaks in Canada from 1988 to 2010.
机构信息
Department of Food Science, Penn State University, University Park, Pennsylvania, USA.
出版信息
J Clin Microbiol. 2012 May;50(5):1748-51. doi: 10.1128/JCM.06185-11. Epub 2012 Feb 15.
Abstract
Human listeriosis outbreaks in Canada have been predominantly caused by serotype 1/2a isolates with highly similar pulsed-field gel electrophoresis (PFGE) patterns. Multilocus sequence typing (MLST) and multi-virulence-locus sequence typing (MVLST) each identified a diverse population of Listeria monocytogenes isolates, and within that, both methods had congruent subtypes that substantiated a predominant clone (clonal complex 8; virulence type 59; proposed epidemic clone 5 [ECV]) that has been causing human illness across Canada for more than 2 decades.
摘要
在加拿大，人类李斯特菌病疫情主要由血清型 1/2a 分离株引起，这些分离株具有高度相似的脉冲场凝胶电泳（PFGE）模式。多位点序列分型（MLST）和多毒力基因座序列分型（MVLST）分别鉴定出李斯特菌属不同的单增李斯特菌分离株群体，其中两种方法都有一致的亚型，证实了一个主要的克隆（克隆复合体 8；毒力型 59；流行克隆 5 [ECV]），该克隆已经在加拿大造成人类疾病超过 20 年。
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