Department of Pathology, M.D. Anderson Cancer Center, Houston, TX 77030, USA.
Am J Clin Pathol. 2012 Mar;137(3):444-50. doi: 10.1309/AJCP76KEGWQKWOKA.
We describe 250 cases of thymoma with emphasis on World Health Organization (WHO) histologic subtyping. The patients were 120 males and 130 females between the ages of 13 and 92 years. Surgical resection was performed, and histologic material was evaluated in every case. Macroscopically, the tumors varied in size from 3 to 20 cm in greatest diameter; about 12% were encapsulated, and about 88% were invasive tumors. A minimum of 5 sections of tumor was evaluated. Histologically, following the schema proposed by the WHO, 21.6% of thymomas were type A, 1.23% type B1, 3.2% type B2, and 9.2% type B3. More than 50% of tumors after subtyping fell into the mixed categories, which, in essence, diminishes the clinical impact of histologic subtyping over staging. The study herein described highlights that all thymomas had the potential to become invasive tumors.
我们描述了 250 例胸腺瘤病例，重点介绍了世界卫生组织（WHO）的组织学亚型。这些患者为 13 至 92 岁的 120 名男性和 130 名女性。所有患者均接受了手术切除，并对组织学标本进行了评估。大体上，肿瘤的最大直径从 3 至 20 厘米不等；约 12%的肿瘤为包膜型，约 88%的肿瘤为侵袭性肿瘤。每个肿瘤至少评估 5 个切片。按照 WHO 提出的方案，21.6%的胸腺瘤为A型，1.23%为 B1 型，3.2%为 B2 型，9.2%为 B3 型。超过 50%的肿瘤在进行亚型分类后归入混合类别，这实际上降低了组织学亚型分类对分期的临床影响。本文的研究强调了所有胸腺瘤都有可能成为侵袭性肿瘤。
