Department of Pathology, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Am J Clin Pathol. 2012 Mar;137(3):462-5. doi: 10.1309/AJCPI41QOQUSKDGP.
There is substantial variation in the reported rates of different diagnostic categories in The Bethesda System for Reporting Thyroid Cytopathology (TBS). Specifically, the relationship between the nondiagnostic (ND) and atypia of undetermined significance (AUS) categories has not been closely examined previously. Data from published series in the literature and from 2 separate hospitals with more than 15,000 thyroid aspirates were reviewed. The AUS and ND rates were consistently negatively correlated when analyzed by year, aspirator, and cytologist. The strongest correlation was with cytologists (P < .0003). Absolute ND rates decreased by 1% for every 3.5% increase in AUS, implying the existence of a discrete population of cases that cytologists will classify as ND or AUS. As such, AUS and ND are not independent variables. Awareness of this relationship may be useful for laboratories and individual cytopathologists for refining the use of TBS.
在《甲状腺细胞病理学报告的 Bethesda 系统》（TBS）中，不同诊断类别的报告率存在很大差异。具体来说，以前并未密切检查非诊断性（ND）和意义不明确的非典型性（AUS）类别之间的关系。对文献中发表的系列数据和来自两家拥有超过 15000 例甲状腺抽吸物的医院的数据进行了回顾。分析年度、抽吸器和细胞学专家时，AUS 和 ND 率始终呈负相关。与细胞学专家的相关性最强（P <.0003）。AUS 增加 3.5%，则 ND 率绝对下降 1%，这意味着存在一个细胞学专家会将其归类为 ND 或 AUS 的离散病例群。因此，AUS 和 ND 不是独立变量。了解这种关系可能对实验室和个别细胞病理学家在使用 TBS 方面有用。
