Department of Obstetrics and Gynecology, Magna Graecia University of Catanzaro, Catanzaro, Italy.
Diabetes Care. 2012 Apr;35(4):861-7. doi: 10.2337/dc11-1971. Epub 2012 Feb 14.
To test the hypothesis that the risk of persistent glucose impairment after gestational diabetes mellitus (GDM) is increased in patients with polycystic ovary syndrome (PCOS).
The prospective case-control study included 42 pregnant patients with PCOS and GDM and 84 pregnant control patients with GDM but without clinical and biochemical hyperandrogenism, polycystic ovaries, and oligo-anovulation. The case and control subjects were matched one to two for age and BMI. The glycemic profiles were studied in all subjects 6 weeks, 12 weeks, and 18 months after delivery. The incidence and the relative risk (RR) were calculated for overall persistence of an abnormal glycemic pattern and for each specific alteration, i.e., impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus (DM).
At 18 months after delivery, the incidences of IFG, IGT, and IFG-IGT were significantly (P < 0.05) higher in the cases than in the controls. At the 18-month follow-up, the RR for the composite outcome of glucose metabolism impairment in PCOS women was 3.45 (95% CI 1.82-6.58).
Patients with PCOS are at increased risk for a persistent impaired glucose metabolism after GDM.
检验这样一个假设，即患有多囊卵巢综合征（PCOS）的患者在妊娠糖尿病（GDM）后持续葡萄糖受损的风险增加。
这项前瞻性病例对照研究纳入了 42 名患有 PCOS 和 GDM 的孕妇和 84 名患有 GDM 但无临床和生化高雄激素血症、多囊卵巢和少排卵的孕妇对照。病例组和对照组按照年龄和 BMI 1:2 匹配。所有受试者在分娩后 6 周、12 周和 18 个月时研究血糖谱。计算总体异常血糖模式以及每种特定改变（即糖耐量受损、空腹血糖受损和糖尿病）的持续存在的发生率和相对风险（RR）。
在分娩后 18 个月时，病例组的 IFG、IGT 和 IFG-IGT 发生率明显高于对照组（P < 0.05）。在 18 个月的随访中，PCOS 女性发生葡萄糖代谢异常的复合结局的 RR 为 3.45（95%CI 1.82-6.58）。
患有 PCOS 的患者在 GDM 后存在持续葡萄糖代谢受损的风险增加。
