Al-Ojaimi Eftekhar H
Department of Obstetrics and Gynecology, Salmaniya Meidcal Complex, Ministry of Health, Kingdom of Bahrain.
Saudi Med J. 2006 Apr;27(4):519-25.
To study whether there is an increased risk of glucose intolerance and hypertensive complications during pregnancy in women with polycystic ovarian syndrome (PCOS) who conceived after laparoscopic ovarian drilling and to investigate if there is an adverse pregnancy outcome.
This prospective study took place at Salmaniya Medical Complex in Bahrain, between June 1996 and June 2003. We compared the pregnancy and neonatal outcomes of 134 patients with PCOS who were treated with laparoscopic ovarian drilling with 479 pregnant women without PCOS (controls). We used the multiple logistic regression analysis to assess the risk of PCOS on impaired glucose tolerance (IGT), gestational diabetes mellitus (GDM), hypertensive disorders in pregnancy (HDP) and premature delivery.
Subjects with PCOS had a significantly greater prepregnancy body mass index, prevalence of obesity and nulliparity as compared with controls. The incidence of IGT (p=0.007), GDM (p=0.01) and HDP (p=0.001) were significantly higher in pregnant PCOS compared with the control group. There were no significant differences in the neonatal outcomes and prevalence of premature delivery between the 2 study groups. When non-obese PCOS patients were compared with non-obese controls, the incidence of GDM (p=0.04) and HDP (p=0.004) were still significantly higher in the former. The prevalence of pregnancy complications were not significantly different when obese PCOS were compared with obese control patients. The PCOS was demonstrated as a risk factor for IGT (p=0.05), GDM (p=0.03) and HDP (p=0.03), but not for premature delivery.
Women with PCOS who conceived after the drilling were at higher risk of IGT, GDM and HDP, and this risk seemed to be independent of maternal obesity.
研究多囊卵巢综合征（PCOS）患者在腹腔镜卵巢打孔术后妊娠期间糖耐量异常和高血压并发症风险是否增加，并调查是否存在不良妊娠结局。
这项前瞻性研究于1996年6月至2003年6月在巴林的萨勒曼尼亚医疗中心进行。我们比较了134例接受腹腔镜卵巢打孔术治疗的PCOS患者与479例无PCOS的孕妇（对照组）的妊娠和新生儿结局。我们使用多元逻辑回归分析来评估PCOS对糖耐量受损（IGT）、妊娠期糖尿病（GDM）、妊娠高血压疾病（HDP）和早产的风险。
与对照组相比，PCOS患者孕前体重指数、肥胖患病率和未生育比例显著更高。与对照组相比，PCOS孕妇中IGT（p = 0.007）、GDM（p = 0.01）和HDP（p = 0.001）的发生率显著更高。两个研究组之间的新生儿结局和早产患病率没有显著差异。当非肥胖PCOS患者与非肥胖对照组进行比较时，前者的GDM（p = 0.04）和HDP（p = 0.004）发生率仍然显著更高。肥胖PCOS患者与肥胖对照患者相比，妊娠并发症的患病率没有显著差异。PCOS被证明是IGT（p = 0.05）、GDM（p = 0.03）和HDP（p = 0.03）的危险因素，但不是早产的危险因素。
腹腔镜卵巢打孔术后妊娠的PCOS患者发生IGT、GDM和HDP的风险更高，且这种风险似乎与孕妇肥胖无关。
