11例伴t(7;11)(p15;p15)易位的急性髓系白血病患者的临床与实验室研究

[Clinical and laboratory studies of 11 acute myeloid leukemia patients with t(7;11) (p15;p15) translocation].

作者信息

Wang Si-Ping, Wei Shu-Ning, Qi Jun-Yuan, Liu Xu-Ping, Yang Hong-Le, Zhao Jia-Wei, An Gang, Wang Jian-Xiang

机构信息

Institute of Hematology and Blood Diseases Hospital, CAMS & PUMC, Tianjin 300020, China.

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2011 Aug;32(8):533-6.

PMID:22338176

Abstract

OBJECTIVE

To investigate clinical and laboratory characteristics of acute myeloid leukemia (AML) patients with t(7;11)(p15;p15).

METHODS

Eleven patients with t(7;11)(p15;p15) were retrospectively reviewed involved in cell morphology, immunophenotype, cytogenetics as well as clinical features and prognosis.

RESULTS

Eight patients out of the eleven were female, six patients were AML-M2a, two M4, two M5, and one M6. All the 11 cases expressed CD33, 10 expressed CD117 and CD13, HLA-DR and CD34 was expressed in 7 and 6 patients, respectively. Karyotypes of all the patients were t(7;11) (p115;p15), additional trisomy 8 were found in only one patient. FLT3-ITD was positive in one of nine patients who were analysed for FLT3-ITD and FLT3-TKD. Two patients were alive, and one lost to followed up, while the rest of eight were dead.

CONCLUSION

The t(7;11) (p15;p15) abnormalities is one of rare chromosomal translocation in patients with AML. AML patients with t(7;11) (p15;p15) have clinical features of anemia, thrombocytopenia, higher white blood cell, and poor prognosis.

摘要

目的

探讨伴有t(7;11)(p15;p15)的急性髓系白血病（AML）患者的临床及实验室特征。

方法

回顾性分析11例伴有t(7;11)(p15;p15)的AML患者的细胞形态学、免疫表型、细胞遗传学以及临床特征和预后。

结果

11例患者中8例为女性，6例为AML-M2a，2例为M4，2例为M5，1例为M6。11例均表达CD33，10例表达CD117和CD13，7例和6例分别表达HLA-DR和CD34。所有患者的核型均为t(7;11)(p115;p15)，仅1例患者发现额外的8号染色体三体。在9例进行FLT3-ITD和FLT3-TKD分析的患者中，1例FLT3-ITD阳性。2例存活，1例失访，其余8例死亡。