Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 288 Nanjing Road, Tianjin 300020, China.
Leuk Res. 2013 Sep;37(9):1010-5. doi: 10.1016/j.leukres.2013.05.020. Epub 2013 Jun 22.
The cellular and molecular genetic aberrations of hematopoietic and lymphoid tissues are increasingly important in leukemia classification and are prognostically significant. Although some recurrent molecular cytogenetic abnormalities in AML have been extensively studied, others including t(7;11)(p15;p15) have not been well characterized. In this paper, seventeen AML patients with t(7;11)(p15;p15) were retrospectively reviewed for cell morphology, immuno-phenotype, cytogenetics as well as clinical features and prognosis. Among them, thirteen were female; nine were AML-M2. Six patients who were newly diagnosed were alive, one was lost for followed up and ten died. The median survival was 8 months. Taking together, AML with t(7;11)(p15;p15) is a rare and distinct disease. Most patients with this translocation are female at younger age and have special clinical and hematological characteristics such as M2-subtype of AML, easy to relapse and poor prognosis.
造血和淋巴组织的细胞和分子遗传学异常在白血病分类中越来越重要，并且具有预后意义。虽然已经对 AML 中的一些常见的分子细胞遗传学异常进行了广泛研究，但其他异常，如 t(7;11)(p15;p15)，尚未得到很好的描述。在本文中，我们回顾性分析了 17 例 t(7;11)(p15;p15)的 AML 患者的细胞形态、免疫表型、细胞遗传学以及临床特征和预后。其中，女性 13 例，AML-M2 9 例。新诊断的 6 例患者存活，1 例失访，10 例死亡。中位生存期为 8 个月。综上所述，t(7;11)(p15;p15)AML 是一种罕见且独特的疾病。大多数携带这种易位的患者为年轻女性，具有 AML-M2 亚型、易复发和预后不良等特殊的临床和血液学特征。
