Wakabayashi K
Carcinogenesis Division, National Cancer Center Research Institute, Tokyo, Japan.
Mutat Res. 1990 Nov;239(3):181-7. doi: 10.1016/0165-1110(90)90005-v.
It is very important to elucidate the causative agents of atherosclerosis because coronary heart disease and cerebrovascular disease are the main causes of death in the developed countries. The evidence for a monoclonal origin of atherosclerotic plaques in humans prompted the study of the involvement of mutagens/carcinogens in the development of atherosclerosis. Polycyclic hydrocarbons, including 7,12-dimethylbenz[a]anthracene and benzo[a]pyrene, were shown to act as initiators and/or accelerators in atherosclerotic plaque formation in the chicken, pigeon and mouse. Radiation and oxygen radicals were also demonstrated to be involved in the development of atherosclerosis in animals.
阐明动脉粥样硬化的致病因素非常重要，因为冠心病和脑血管疾病是发达国家的主要死因。人类动脉粥样硬化斑块单克隆起源的证据促使人们研究诱变剂/致癌物在动脉粥样硬化发展中的作用。包括7,12-二甲基苯并[a]蒽和苯并[a]芘在内的多环烃已被证明在鸡、鸽和小鼠的动脉粥样硬化斑块形成中起引发剂和/或促进剂的作用。辐射和氧自由基也被证明与动物动脉粥样硬化的发展有关。
