甲基乙烯基砜：一类新型的迈克尔型基因毒素。

Methyl vinyl sulphone: a new class of Michael-type genotoxin.

作者信息

Warr T J, Parry J M, Callander R D, Ashby J

机构信息

School of Biological Sciences, University College of Swansea, Singleton Park, Great Britain.

出版信息

Mutat Res. 1990 Nov;245(3):191-9. doi: 10.1016/0165-7992(90)90049-p.

DOI:10.1016/0165-7992(90)90049-p

PMID:2233840

Abstract

Methyl vinyl sulphone (MVS) is a labile, Michael-reactive chemical, similar in structure to acrylamide (AA). Given that acrylamide is a reference mammalian mutagen and a rodent carcinogen, studies were undertaken to evaluate the potential genotoxicity of MVS. In common with AA, MVS was non-mutagenic to Salmonella but active as an aneugen to cultured mammalian cells. It is concluded that vinyl sulphones should be regarded as representative of a new class of genotoxic chemical whose mode of action is probably primarily dependent upon Michael reactivity to proteins.

摘要

甲基乙烯基砜（MVS）是一种不稳定的、具有迈克尔反应活性的化学物质，其结构与丙烯酰胺（AA）相似。鉴于丙烯酰胺是一种参考哺乳动物诱变剂和啮齿动物致癌物，因此开展了研究以评估MVS的潜在遗传毒性。与AA一样，MVS对沙门氏菌无致突变性，但对培养的哺乳动物细胞有染色体分离异常剂活性。得出的结论是，乙烯基砜应被视为一类新的遗传毒性化学物质的代表，其作用模式可能主要取决于对蛋白质的迈克尔反应活性。