丙烯酰胺在真核系统中具有致突变活性，但在细菌中则不然。

Mutagenic activity of acrylamide in eukaryotic systems but not in bacteria.

作者信息

Knaap A G, Kramers P G, Voogd C E, Bergkamp W G, Groot M G, Langebroek P G, Mout H C, van der Stel J J, Verharen H W

机构信息

National Institute of Public Health and Environmental Protection, Laboratory of Carcinogenesis and Mutagenesis, Bilthoven, The Netherlands.

出版信息

Mutagenesis. 1988 May;3(3):263-8. doi: 10.1093/mutage/3.3.263.

DOI:10.1093/mutage/3.3.263

PMID:3137422

Abstract

The vinyl monomer acrylamide (AA) was studied for its activity in a range of genotoxicity tests, including the Salmonella/microsome test, the fluctuation test using Klebsiella pneumoniae, the test for gene mutations at the TK and HPRT loci in L5178Y mouse lymphoma cells, tests for chromosomal aberrations and SCEs in V79 Chinese hamster cells, the sex-linked recessive lethal (SLRL) and somatic mutation and recombination (SMART) assays in Drosophila melanogaster and the mouse bone marrow micronucleus assay. AA showed genotoxic activity in most systems. The bacterial tests did not respond, in compliance with literature data; also in the Drosophila SLRL test, no significant increase in mutation rate was observed.

摘要

对乙烯基单体丙烯酰胺（AA）进行了一系列遗传毒性试验，包括沙门氏菌/微粒体试验、使用肺炎克雷伯菌的波动试验、L5178Y小鼠淋巴瘤细胞中TK和HPRT位点的基因突变试验、V79中国仓鼠细胞中的染色体畸变和姐妹染色单体交换试验、黑腹果蝇中的性连锁隐性致死（SLRL）和体细胞突变与重组（SMART）试验以及小鼠骨髓微核试验，以研究其活性。AA在大多数系统中表现出遗传毒性活性。细菌试验无反应，这与文献数据一致；在果蝇SLRL试验中，也未观察到突变率有显著增加。