Department of Neuroscience and Biomedical Technologies, University of Milano-Bicocca, Via Cadore 48, 20900 Monza (MB), Italy.
Curr Med Chem. 2012;19(9):1269-76. doi: 10.2174/092986712799462711.
Glutamate is one of the major neurotrasmitters in mammalian brain and changes in its concentration have been associated with a number of neurological disorders, including neurodegenerative, cerebrovascular diseases and epilepsy. Moreover, recently a possible role for glutamatergic system dysfunction has been suggested also in the peripheral nervous system. This chapter will revise the current knowledge in the distribution of glutamate and of its receptors and transporters in the central nervous system.
谷氨酸是哺乳动物大脑中的主要神经递质之一，其浓度的变化与许多神经疾病有关，包括神经退行性疾病、脑血管疾病和癫痫。此外，最近有研究表明，谷氨酸能系统功能障碍也可能与周围神经系统有关。本章将综述谷氨酸及其受体和转运体在中枢神经系统中的分布的最新知识。
