Haacke E Mark, Beggs Clive B, Habib Charbel
Wayne State University, MR Research Facility, Department of Radiology, HUH-MR Research, G030/Radiology, 3990 John R Road, Detroit, MI 48201, USA.
Rev Recent Clin Trials. 2012 May;7(2):100-16. doi: 10.2174/157488712800100305.
The role of the venous circulation has long been underestimated in clinical practice and in research into neurological diseases. In this review, we present an overview of the existing evidence that venous abnormalities can play a key role in the development and manifestation of neurological and neurodegenerative diseases. We review the history behind the role of venous diseases in multiple sclerosis and their connections with the disease landmarks, the links of chronic venous hypertension to cerebral hydrodynamics and the role of iron in MS. In addition, we highlight the role of venous abnormalities in other diseases including jugular venous reflux, developmental anomalies, hydrocephalus and cerebrospinal fluid flow. Finally, and based on the information presented throughout the whole review, we conclude with the link between chronic cerebrospinal venous insufficiency and MS and the role and power of magnetic resonance imaging in diagnosing venous anomalies.
在临床实践以及神经疾病研究中，静脉循环的作用长期以来一直被低估。在这篇综述中，我们概述了现有证据，即静脉异常在神经和神经退行性疾病的发生和表现中可能起关键作用。我们回顾了静脉疾病在多发性硬化症中的作用背后的历史及其与疾病标志性特征的联系、慢性静脉高压与脑流体动力学的联系以及铁在多发性硬化症中的作用。此外，我们强调了静脉异常在其他疾病中的作用，包括颈静脉反流、发育异常、脑积水和脑脊液流动。最后，基于整个综述中呈现的信息，我们总结了慢性脑脊髓静脉功能不全与多发性硬化症之间的联系以及磁共振成像在诊断静脉异常中的作用和功效。
