Kitareewan Walaiporn, Boonhong Jariya, Janchai Siriporn, Aksaranugraha Sek
Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
J Med Assoc Thai. 2011 Oct;94 Suppl 5:S10-6.
To study the effects of moderate-intensity treadmill walking exercise on the biochemical bone markers in the menstruating and menopausal women.
Experimental study.
Department of Rehabilitation Medicine, King Chulalongkorn Memorial Hospital.
Twenty-two healthy volunteer women at the age of 30-70 were recruited: 11 menstruating women and 11 menopausal women. The exercise consisted of the treadmill walking exercise, intensity of 50% of heart rate reserve, for the duration of 30 minutes, at the frequency of 3 times a week, over a 3-month period. Serum beta CTx, PINP and NMID osteocalcin were measured at the baseline and in the 1st, 2nd, and 3rd months.
Twenty women: 11 menstruating women and 9 menopauses completed the exercise protocol. The baseline characteristics including age, body mass index, serum beta CTx, PINP and NMID were statistically different. The serum beta CTx and NMID levels were decreased from the baseline from Month 1 to 3 in both menstruating and menopausal groups. Serum PINP was not significantly changed in the 1st and 2nd months except the significant decreasing in the 3rd month in the menstruating women. There were no significant differences of bone marker changes between the menstruating women and the menopauses. The biochemical bone markers' levels (beta CTx, PINP and NMID) had the strong correlations analyzed by Pearson's correlation coefficients (> 0.8 with p-value < 0.001).
The present study clearly demonstrates that the moderate intensity treadmill walking exercise for 30 minutes, 3 times a week reduces bone resorption and bone turnover markers in both the menstruating women and the menopauses after the first month until the third month of the experiment. Although the bone formation markers had a tendency of decreasing after exercising, the significant changes showed only in the 3rd month in the menstruating group. All of the bone markers including beta CTx, NMID osteocalcin and PINP were highly correlated.
研究中等强度跑步机步行运动对处于月经周期的女性和绝经后女性生化骨标志物的影响。
实验性研究。
朱拉隆功国王纪念医院康复医学科。
招募了22名年龄在30 - 70岁的健康志愿者女性：11名处于月经周期的女性和11名绝经后女性。运动包括跑步机步行运动，心率储备强度的50%，持续30分钟，每周3次，为期3个月。在基线以及第1、2和3个月时测量血清β-CTX、PINP和NMID骨钙素。
20名女性（11名处于月经周期的女性和9名绝经后女性）完成了运动方案。包括年龄、体重指数、血清β-CTX、PINP和NMID在内的基线特征在统计学上存在差异。在月经周期女性组和绝经后女性组中，从第1个月到第3个月，血清β-CTX和NMID水平均较基线下降。月经周期女性组除第3个月显著下降外，第1和第2个月血清PINP无显著变化。月经周期女性和绝经后女性之间骨标志物变化无显著差异。通过Pearson相关系数分析，生化骨标志物水平（β-CTX、PINP和NMID）具有强相关性（相关系数>0.8，p值<0.001）。
本研究清楚地表明，每周3次、每次30分钟的中等强度跑步机步行运动，在实验的第1个月至第3个月期间，可降低月经周期女性和绝经后女性的骨吸收和骨转换标志物。尽管运动后骨形成标志物有下降趋势，但仅在月经周期女性组的第3个月出现显著变化。包括β-CTX、NMID骨钙素和PINP在内的所有骨标志物都高度相关。
