Plinta Ryszard, Czajkowska Mariola, Pisula Magdalena, Brzęk Anna, Knapik Andrzej, Olszanecka-Glinianowicz Magdalena, Skrzypulec-Plinta Violetta
Department of Adapted Physical Activity and Sport, Chair of Physiotherapy, Medical University of Silesia in Katowice, School of Health Sciences in Katowice, Poland.
Chair of Woman's Health, Medical University of Silesia in Katowice, School of Health Sciences in Katowice, Poland.
Arch Med Sci. 2020 Oct 3;19(3):586-592. doi: 10.5114/aoms.2020.99624. eCollection 2023.
Regular physical activity (PA) is a recognized factor stimulating bone formation. In recent years, osteocytes have been shown to be involved in the metabolism of bone tissue in addition to osteoblasts and osteoclasts. The aim of the study was to analyze the effects of regular fitness training, sex hormones, and selected bone turnover markers on sclerostin levels in young women.
The cross-sectional study involved 78 women including 39 who regularly engaged in fitness training (for 1 h three times a week for 3 months) and 39 leading a sedentary lifestyle. Anthropometric measurements and glucose, lipids, insulin, estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate, intact parathyroid hormone (iPTH), vitamin D, osteocalcin, β isomer of C-terminal telopeptide of type I collagen (β-CTx) and sclerostin levels were measured.
Activity of women (study group) who were on a high level of PA ranged between 2262 and 6606 MET/min/week (mean, 3843.16; SD = 1230). All of the control group were on low level of PA (198-1617 MET/min/week; mean, 841.06; SD = 302.01). Significantly higher levels of iPTH and β-CTx were observed in the study than in the control group ( < 0.01). We did not observe differences in vitamin D ( > 0.12), osteocalcin ( > 0.23), or sclerostin levels ( > 0.37) between groups. There were significant negative correlations between log10 sclerostin and log10 DHEA levels ( = -0.24; < 0.05). A multivariate stepwise backward linear regression model for sclerostin as an independent variable, with the explanatory variables physical activity, estradiol, testosterone, and DHEA levels, did not reveal any effect on changes of sclerostin levels. The model with the explanatory variables vitamin D, iPTH, β-CTx, and osteocalcin also did not show effects on changes of sclerostin levels.
Our results show that regular fitness training, sex hormones, vitamin D, iPTH, β-CTx, and osteocalcin did not influence circulating sclerostin levels in young women.
规律的体育活动（PA）是刺激骨形成的一个公认因素。近年来，除了成骨细胞和破骨细胞外，骨细胞也被证明参与骨组织的代谢。本研究的目的是分析规律健身训练、性激素和选定的骨转换标志物对年轻女性硬化素水平的影响。
这项横断面研究纳入了78名女性，其中39名经常进行健身训练（每周三次，每次1小时，共3个月），39名久坐不动。测量了人体测量指标、血糖、血脂、胰岛素、雌二醇、睾酮、游离睾酮、雄烯二酮、脱氢表雄酮（DHEA）、硫酸脱氢表雄酮、完整甲状旁腺激素（iPTH）、维生素D、骨钙素、I型胶原C末端肽β异构体（β-CTx）和硬化素水平。
进行高水平PA的女性（研究组）的活动量在2262至6606代谢当量/分钟/周之间（平均3843.16；标准差=1230）。所有对照组的PA水平较低（198 - 1617代谢当量/分钟/周；平均841.06；标准差=302.01）。研究组中iPTH和β-CTx的水平显著高于对照组（<0.01）。我们未观察到两组之间维生素D（>0.12）、骨钙素（>0.23）或硬化素水平（>0.37）存在差异。log10硬化素与log10 DHEA水平之间存在显著负相关（=-0.24；<0.05）。以硬化素为自变量，并将体育活动、雌二醇、睾酮和DHEA水平作为解释变量的多元逐步向后线性回归模型，未显示对硬化素水平变化有任何影响。以维生素D、iPTH、β-CTx和骨钙素为解释变量的模型也未显示对硬化素水平变化有影响。
我们的结果表明，规律的健身训练、性激素、维生素D、iPTH、β-CTx和骨钙素不会影响年轻女性循环中的硬化素水平。
