Oh Daniel S, Adamson David C, Kirkpatrick John P
Duke University Medical Center, DUMC, Durham, NC 27710, USA.
Curr Drug Discov Technol. 2012 Dec;9(4):268-79. doi: 10.2174/157016312803305870.
Malignant glioma remains a disease with poor prognosis despite recent advances in the multidisciplinary care of this disease. Herein we review the evolution of and recent advances in radiation therapy for malignant glioma that have allowed for more targeted therapy, potentially improving efficacy while decreasing normal tissue toxicity. Current and emerging techniques are presented, including stereotactic radiotherapy and radiosurgery, brachytherapy, radioimmunotherapy, and charged particle therapy, as well as the combination of these modalities with novel targeted biochemotherapies.
尽管恶性胶质瘤在多学科治疗方面取得了最新进展，但其预后仍然很差。在此，我们回顾了恶性胶质瘤放射治疗的发展历程和最新进展，这些进展使得治疗更具针对性，有望在提高疗效的同时降低正常组织毒性。本文介绍了当前和新兴的技术，包括立体定向放射治疗和放射外科、近距离放射治疗、放射免疫治疗和带电粒子治疗，以及这些治疗方式与新型靶向生物化疗的联合应用。
