Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
J Org Chem. 2012 Mar 16;77(6):2992-8. doi: 10.1021/jo300036d. Epub 2012 Feb 28.
We report a Pd-catalyzed direct arylation of polyfluoroarenes with aryl iodides. The advantages of this reaction are its high reaction efficiency, excellent functional group compatibility, mild reaction conditions (70 °C), inexpensive PPh(3) ligand, and use of pure water as reaction medium. The usefulness of this reaction has also been demonstrated by rapid preparation of highly functionalized polyfluoroarenes via iterative Pd-catalyzed C-H bond functionalization.
我们报告了钯催化的多氟芳烃与芳基碘化物的直接芳基化反应。该反应的优点是反应效率高、官能团兼容性好、反应条件温和（70°C）、使用廉价的 PPh(3)配体以及以纯水作为反应介质。通过快速制备高度官能化的多氟芳烃，也证明了该反应的有用性，这是通过迭代的钯催化 C-H 键官能化实现的。
