Hg(OTf)2 催化的乙烯基半频哪醇重排反应生成 1,4-二氢喹啉。
Hg(OTf)2-catalyzed vinylogous semi-pinacol rearrangement leading to 1,4-dihydroquinolines.
机构信息
Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan.
出版信息
Org Lett. 2012 Mar 2;14(5):1222-5. doi: 10.1021/ol2034492. Epub 2012 Feb 16.
PMID:22339178
Abstract
An efficient method for the construction of dihydroquinoline derivatives possessing a quaternary carbon center is developed by an application of Hg(OTf)(2)-catalyzed vinylogous semi-pinacol-type rearrangement. The reaction was found to be specifically catalyzed by mercury salt and to proceed via a bicyclic aminal.
摘要
发展了一种通过 Hg(OTf)(2)催化的 vinylogous 半频哪醇型重排反应构建具有季碳中心的二氢喹啉衍生物的有效方法。反应被发现是由汞盐特异性催化的，且经过双环亚胺中间体进行。
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